Criteria for hygienic assessment of ambient air concentrations of industrial aerosols with a high content of amorphous silicon dioxide nanoparticles

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The authors consider critically some inconsistencies of applying the officially established standards for inorganic dust permissible concentrations in ambient air to amorphous silica nanoparticles-containing industrial aerosols and, relying upon their previously published experimental results, propose a feasible temporary solution to this problem for the purposes of hygienic monitoring.

Sobre autores

S. Solovyeva

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Autor responsável pela correspondência
Email: noemail@neicon.ru
Rússia

M. Sutunkova

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: noemail@neicon.ru
Rússia

Boris Katsnelson

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: bkaznelson@ymrc.ru

MD, PhD, DSci, Professor,  Head of the Toxicology and Biological Prophylaxis Department, Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Ekaterinburg,  620014, Russian Federation.

e-mail: bkaznelson@ymrc.ru

Rússia

Bibliografia

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  2. Vance M.E., Kuiken T., Vejerano E.P., McGinnis S.P., Hochella M.F., Rejeski D., et al. Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory. Beilstein J. Nanotechnol. 2015; 6: 1769-806.
  3. Park E.J., Park K. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol. Lett. 2009; 184(1): 18-25.
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  5. Kim Y.J., Yu M., Park H.O., Yang S.I. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by silica nanomaterials in human neuronal cell line. Mol. Cell. Toxicol. 2010; 6(4): 336-43.
  6. Sergent J.A., Paget V., Chevillard S. Toxicity and genotoxicity of nano-SiO2 on human epithelial intestinal HT-29 cell line. Ann. Occup. Hyg. 2012; 56(5): 622-30.
  7. Du Z.J., Zhao D.L., Jing L., Cui G., Jin M., Li Y., et al. Cardiovascular toxicity of different sizes amorphous silica nanoparticles in rats after intratracheal instillation. Cardiovasc. Toxicol. 2013; 13(3): 194-207.
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  9. Guo C., Xia Y., Niu P., Jiang L., Duan J., Yu Y., et al. Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling. Int. J. Nanomedicine. 2015; (10): 1463-77.
  10. Guo C., Yang M., Jing L., Wang J., Yu Y., Li Y., et al. Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling. Int. J. Nanomedicine. 2016; (11): 5257-76.
  11. Wang J., Yu Y., Lu K., Yang M., Li Y., Zhou X., et al. Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes. Int. J. Nanomedicine. 2017; (12): 809-25.
  12. Sutunkova M.P., Solov’eva S.N., Katsnel’son B.A., Gurvich B.B., Privalova L.I., Minigalieva I.A., et al. Some peculiarities of organism’s responses to a long-term inhalation of silica-containing submicron (predominantly, nanoscale) particles of a real industrial aerosol. Toksikologicheskiy vestnik. 2017; 144(3): 17-26. (in Russian)
  13. Sutunkova M.P., Solovyeva S.N., Katsnelson B.A., Gurvich V.B., Privalova L. I., Minigalieva I.A., et al. A paradoxical response of the rat organism to long-term inhalation of silica-containing submicron (predominantly nanoscale) particles of a collected industrial aerosol at realistic exposure levels. Toxicology. 2017; 384: 59-68.

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Declaração de direitos autorais © Solovyeva S.N., Sutunkova M.P., Katsnelson B.A., 2024


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