Biological prophylaxis in the system of the management of occupational risk due to exposure of metal-containing nanoparticles

Larisa I. Privalova; Привалова Лариса Ивановна; B. A. Katsnelson; Кацнельсон Б. А.; I. A. Minigalieva; Минигалиева И. А.; M. P. Sutunkova; Сутункова М. П.; O. G. Makeev; Макеев О. Г.; I. E. Valamina; Валамина И. Е.; V. Ya. Shur; Шур В. Я.; S. V. Klinova; Клинова С. В.; S. N. Solovyeva; Соловьёва С. Н.

doi:10.47470/0016-9900-2017-96-12-1187-1191

Biological prophylaxis in the system of the management of occupational risk due to exposure of metal-containing nanoparticles

Autores: Privalova L.I.¹, Katsnelson B.A.¹, Minigalieva I.A.¹, Sutunkova M.P.¹, Makeev O.G.², Valamina I.E.², Shur V.Y.³, Klinova S.V.¹, Solovyeva S.N.¹
Afiliações:
1. Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
2. The Central Research Laboratory of the Ural Medical University
3. Ural Federal University
Edição: Volume 96, Nº 12 (2017)
Páginas: 1187-1191
Seção: PREVENTIVE TOXICOLOGY AND HYGIENIC STANDARTIZATION
##submission.datePublished##: 21.10.2020
URL: https://vestnik.nvsu.ru/0016-9900/article/view/640736
DOI: https://doi.org/10.47470/0016-9900-2017-96-12-1187-1191
ID: 640736

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Texto integral

Resumo

With taking into account the biological toxicity of metallic and metal oxide nanoparticles to be a well-established fact, the widespread use of nanotechnologies and the significant proportion of nanoscale particles in industrial aerosols released during many pyrometallurgical and electric welding processes determine the importance of searching for approaches to increase the organism’s resistance to them. Results of a number of experiments show the application of combinations of some bioactive agents composed in accordance with sound theoretical premises and used in innocuous doses to be potent of the significant attenuation of the integral and specific toxicity of metallic nanoparticles and even their genotoxicity. Further research followed by practical application of the results is a promising trend in the occupational risk management strategy.

Palavras-chave

metallic nanoparticles, bioprotectors

Sobre autores

Larisa Privalova

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Autor responsável pela correspondência
Email: privalovali@yahoo.com
ORCID ID: 0000-0002-1442-6737

MD, PhD, DSci., Professor Head of Laboratory of Scientific Bases for Biological Prophylaxis, Department of the Toxicology and Biological Prophylaxis, the Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, 620014, Russian Federation.

e-mail: privalovali@yahoo.com

Rússia

Bibliografia

Katsnel’son B.A., Privalova L.I., Sutunkova M.P., Minigalieva I.A., Gurvich V.B, Shur V.Y., et al. Experimental research into metallic and metal oxide nanoparticle toxicity in vivo. In: Bioactivity of Engineered Nanoparticles. Ch. 11. Singapore: Springer; 2017: 259-319.
Katsnel’son B.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Minigalieva I.A., Loginova N.V., et al. Main results of toxicological experiments in vivo with some metal and metal oxides nanoparticles. Toksikologicheskiy vestnik. 2015; (3): 26-39. (in Russian)
Katsnel’son B.A., Privalova L.I., Gurvich V.B., Kuzmin S.V., Kireyeva E.P., Minigalieva I.A., et al. Enhancing population’s resistance to toxic exposures as an auxiliary tool of decreasing environmental and occupational health risks (a self-overview). J. Environ. Prot. 2014; 5(14): 1435-49.
Katsnel’son B.A., Privalova L.I., Gurvich V.B., Kuz’min S.V., Kireeva E.P., Minigalieva I.A., et al. The role of bio-prevention in the framework of managing occupational and environmental chemical risks to population health. Toksikologicheskiy vestnik. 2015; (1): 10-21. (in Russian)
Katsnel’son B.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Minigalieva I.A., Loginova N.V., et al. Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview). Int. J. Nanomedicine. 2015; 10: 3013-29.
Katsnel’son B.A., Privalova L.I., Gurvich V.B., Makeyev O.H., Shur V.Ya., Beikin Y.B., et al. Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors. Int. J. Mol. Sci. 2013; 14(2): 2449-83.
Katsnel’son B.A., Makeev O.G., Privalova L.I., Sutunkova M.P., Kireeva E.P., Minigalieva I.A., et al. Comparative genotoxicity of nanosilver and nano-gold and its possible decrease using a complex of bioprotectors. Toksikologicheskiy vestnik. 2013; (2): 20-5. (in Russian)
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Privalova L.I., Katsnel’son B.A., Loginova N.V., Gurvich V.B., Shur V.Y., Valamina I.E., et al. Subchronic Toxicity of Copper Oxide Nanoparticles and Its Attenuation with the Help of a Combination of Bioprotectors. Int. J. Mol. Sci. 2014; 15(7): 12379-406.
Minigalieva I.A., Katsnel’son B.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Shur V.Y., et al. Attenuation of combined nickel (II) oxide and manganese (II, III) oxide nanoparticles’ adverse effects with a complex of bioprotectors. Int. J. Mol. Sci. 2015; 16(9): 22555-83.
Katsnel’son B.A., Minigalieva I.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Shur V.Ya., et al. Lower airways response in rats to a single or combined intratracheal instillation of manganese and nickel nanoparticles and its attenuation with a bio-protective pre-treatment. Toksikologicheskiy vestnik. 2014; (6): 8-14. (in Russian)
Minigalieva I.A., Katsnel’son B.A., Panov V.G., Privalova L.I., Varaksin A.N., Gurvich V.B., et al. In vivo toxicity of copper oxide, lead oxide and zinc oxide nanoparticles acting in different combinations and its attenuation with a complex of innocuous bio-protectors. Toxicology. 2017; 380: 72-93.
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Katsnel’son B.A., Privalova L.I., Gurvich V.B., Makeev O.G., Shur V.Ya., Sutunkova M.P., et al. Method for prevention of adverse effect of general toxic and genotoxic action of nanosilver on human body. Patent RF №2530639; 2014. (in Russian)
Katsnel’son B.A., Privalova L.I., Gurvich V.B., Makeev O.G., Shur V.Ya., Sutunkova M.P., et al. Method for prevention of adverse health effects of general toxic and genotoxic action of copper oxide nanoparticles. Patent RF №2560682; 2015. (in Russian)
Minigalieva I.A., Katsnel’son B.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Shur V.Ya., et al. Method of increasing body resistance to chronic combined toxic effect of nanoparticles of nickel oxide and manganese oxide. Patent RF №2597157; 2016. (in Russian)

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Biological prophylaxis in the system of the management of occupational risk due to exposure of metal-containing nanoparticles

Texto integral

Resumo

Palavras-chave

Sobre autores

Larisa Privalova

B. Katsnelson

I. Minigalieva

M. Sutunkova

O. Makeev

I. Valamina

V. Shur

S. Klinova

S. Solovyeva

Bibliografia

Arquivos suplementares