THE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOOD

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Abstract

In experiments on outbred albino rats, it was established that subacute intoxication with ethylene chlorohydrin (0.2 LD50 daily for 4 days) causes a decrease in Th1 and Th2 lymphocytes function to the same extent, diminishes parameters of humoral and cellular immune responses and the content of immunoregulatory cytokines IFN- , IL-2, IL-4 in blood, increases concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.

About the authors

P. F. Zabrodskii

Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

V. V. Maslyakov

Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”

Email: noemail@neicon.ru
Russian Federation

M. S. Gromov

Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2017 Zabrodskii P.F., Maslyakov V.V., Gromov M.S.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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