EXPERIMENTAL JUSTIFICATION OF SUPPORTIVE THERAPY WITH ADEMETIONINE FOR THE REDUCTION OF HEPATOTOXIC REACTIONS TO ANTITUBERCULOSIS DRUGS

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Abstract

The article presents the results of experimental toxicological studies on justification of ademetionine supportive therapy in order to prevent toxic liver damage when using antituberculosis drugs.

About the authors

K. I. Usov

Angarsk State Technical University.

Author for correspondence.
Email: fake@neicon.ru
665835, Angarsk. Russian Federation

T. A. Gusʹkova

M.V.Dorogov Yaroslavl Center for the Transfer of Pharmaceutical Technologies, K.D.Yaroslavl State Pedagogical University.

Email: fake@neicon.ru
150010, Yaroslavl. Russian Federation

G. G. Jushkov

Angarsk State Technical University.

Email: fake@neicon.ru
665835, Angarsk. Russian Federation

L. P. Grishina

Irkutsk Regional Pathology and Autopsy Bureau.

Email: fake@neicon.ru
664079, Irkutsk. Russian Federation

A. S. Gushchin

Joint-Stock Company «Pharmasyntez».

Email: fake@neicon.ru
664007, Irkutsk. Russian Federation

References

  1. D.A. Ivanova. Adverse reactions in the treatment of patients with tuberculosis. Tuberculosis and lung disease. 2011; 6: 60-9. (in Russian)
  2. Yu.I. Feshchenko, S.A. Cherenko, V.I. Maltsev. Evaluation of the significance of adverse reactions of antituberculosis drugs in the treatment of tuberculosis. Ukr. med. chronicle. 2008; 5: 117-25. (in Russian)
  3. M. Hartleb, L. Biernat, A. Kochel. Druginduced liver damage – a three year study of patients from one of gastroenterological department. Med Sci Monit. 2002; 8: 292-96.
  4. K.I. Usov. Study of adverse reactions of the drugs isoniazid and possibility of their correction with the help of pyridoxine hydrochloride. The PhD thesis’s of K.I. Usov; Belgorod State National Research University. Belgorod; 20 (in Russian)
  5. G.N. Mozhokina, N.A. Elistratova, L.P. Mikhailova, O.V. Makarova, V.S. Sultanov, V.B. Trusov. Experimental rationale for the use of ropren for the prevention of liver damage caused by isoniazid. Tuberculosis and lung disease. 2014; (7): 47-53. (in Russian)
  6. V. Erokhin, I.A. Panacek, N.V. Adamovich. Clinical and morphological criteria of druginduced hepatitis in pulmonary tuberculosis patients. The problem of tuberculosis. 1991; 1: 35-9. (in Russian)
  7. K.S. Kazakov, A.A. Kalanchondzaev, M.I. Kozarez. Frequency and nature of side effects of anti-TB chemotherapy. The problem of tuberculosis. 1991; 12: 28-31. (in Russian)
  8. D.A. Ivanov, S.E. Borisov. Risk assessment and monitoring of hepatotoxic reactions in patients with tuberculosis. Tuberculosis and lung disease. 2017; 95 (9): 40-8. (in Russian)
  9. D.A. Ivanov, S.E. Borisov. Cancel or wait?: indications for withdrawal of anti-TB drugs in case of adverse reactions. Tuberculosis and lung disease. 2018; 96 (2): 47-54. (in Russian)
  10. V.Yu. Mishin. Medical complications of combined chemotherapy of pulmonary tuberculosis. M.: Medical information Agency; 2007. (in Russian)
  11. S.D. Podymova. Ademetionine: pharmacological effects and clinical application of the drug. BC. 2010; 18 (13): 800-5. (in Russian)
  12. E.V. Biron, M.V. Kalinina. Medicinal liver lesions in patients with tuberculosis and the possibility of their correction. Pharmateca, 2013; 4: 84-92. (in Russian)
  13. RD 64-126-91 «Preclinical safety assessment rules for pharmacological agents (GLP)». Moscow; 1991. (in Russian)
  14. T.A. Gus‒kova. Features of preclinical toxicological study of antibacterial agents. Pharmacology and toxicology. 1985; XLVIII (3): 119-122 (in Russian)
  15. About measures for further improvement of organizational forms of work with use of experimental animals. Available at: http://www.vita.org.ru/exper/orderpeotrovsky.htm. (in Russian)
  16. About the approval of rules of good laboratory practice: the order of the Ministry of Health and Social Development of the Russian Federation of April 01, 2016 No. 199n. Available at: http://www.docs.cntd.ru/document/420350679. (in Russian)
  17. D.S. Sukhanov. Antioxidant properties of remaxol, reamberin and ademetionine in medicinal liver lesions in patients with anti-tuberculosis therapy. Experimental and clinical pharmacology. 2013; 76 (4): 45-8. (in Russian)
  18. D.S. Sukhanov, T.I. Vinogradova, N.V. Zabolotnykh, M.L. Vitovskaya, A.L. Kovalenko. Hepatotropic action of runihole and ademetionine in liver damage with anti-TB drugs of the main range in the experiment. Archives of pathology. 2014; 76 (2): 26-31. (in Russian)
  19. D.S. Sukhanov, E.B. Artyushkova, V.T. Dudka, S.V. Okovitii. The efficiency of remaxol and ademetionine in the combined experimental liver damage with the reserve series of anti-tuberculosis drugs and alcohol. Tuberculosis and lung disease. 2014; № (4): 59-63. (in Russian)
  20. I.P. Kondrakhin. Methods of veterinary clinical laboratory diagnostics: Handbook. M.: Kolos; 2004. (in Russian)
  21. P.K. Yablonsky, red. Phthisiology. National clinical guidelines. M.: GEOTAR-Media, 2016. (in Russian)
  22. N.I. Portanay, V.V. Sokolovsky, B.G. Osipenko. Biochemical studies in toxicological experiment. Irkutsk: ISU; 1990. (in Russian)
  23. P.A. Akimov, A.G. Orbidans, G.A. Terekhin, A.N. Terekhina. The effect of alcohol intoxication on the content of glycogen in the liver and skeletal muscles. Pathological physiology and experimental therapy. 2010; 2: 15-7. (in Russian)
  24. S. Glantz. Medical and biological statistics. M.: Practice, 1999. (in Russian)
  25. K.I. Usov, T.A. Gus’kova, G.G. Yushkov, A.V. Mashanov, A.A. Guschina. Influence of chronobiological rhythms on the toxicity of isoniazid and rifampicin in combined application in experiment on rats. Toxicological Review. 2017; 4: 24-33. (in Russian)

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Copyright (c) 2018 Usov K.I., Gusʹkova T.A., Jushkov G.G., Grishina L.P., Gushchin A.S.


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