ON THE MEANING OF THE TERM «HORMESIS» AND ITS PLACE IN THE GENERAL THEORY OF THE DEPENDENCE OF THE BODY’S RESPONSE TO POTENTIALLY HARMFUL EFFECTS ON ITS STRENGTH

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Abstract

Spherical nanoparticles (NP) of cadmium and lead sulfides (dia.37 ± 5 nm and 24 ± 4 nm, respectively) turned to be cytotoxic for HL-1 cardiomyocytes as illustrated by ATP-dependent luminescence reduction. It was revealed, that CdS-NP affect in a greater degree than PbS-NP. In view of the same dose range, CdS-NP decreased the amount of calcium spikes. Small PbS-NP doses showed the same effect. Besides cell hypertrophy due to certain CdS-NP and PbS-NP impact, doses leading to cardiomyocyte decrease were revealed. In order to correspond with the following three results, both monotonic «dose-response» functions (properly approximated by the hyperbolic function) as well as different variants of non-monotonic ones were deduced by us, for which adequate mathematical expressions through modifying certain hormesis models are to be had in literature. Evidence-based analysis involving response surface linear model as well as a cross term, acknowledged a new support to the formerly inflexible rule stating that the diversity kinds of combined action, typical for the same damaging agents’ pair is of the fundamental propositions in the general theory of combined toxicity.

About the authors

V. G. Panov

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Author for correspondence.
Email: panov@ecko.uran.ru

Panov Vladimir Grigoryevich

620014, Yekaterinburg

Russian Federation

I. A. Minigalieva

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: ilzira-minigalieva@yandex.ru

Minigalieva Ilzira Amirovna

620014, Yekaterinburg

Russian Federation

T. V. Bushueva

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: bushueva@ymrc.ru

Bushueva Tatyana Victorovna

620014, Yekaterinburg

Russian Federation

L. I. Privalova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: privalovali@yahoo.com

Privalova Larisa Ivanovna

620014, Yekaterinburg

Russian Federation

S. V. Klinova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: klinovasv@ymrc.ru

Klinova Svetlana Vladislavovna

620014, Yekaterinburg

Russian Federation

V. B. Gurviсh

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: gurvich@ymrc.ru

Gurvich Vladimir Borisovich

620014, Yekaterinburg

Russian Federation

M. P. Sutunkova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: sutunkova@ymrc.ru

Sutunkova Marina Petrovna

620014, Yekaterinburg

Russian Federation

B. A. Katsnelson

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: bkaznelson@etel.ru

Katsnelson Boris Aleksandrovich

620014, Yekaterinburg

Russian Federation

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Copyright (c) 2020 Panov V.G., Minigalieva I.A., Bushueva T.V., Privalova L.I., Klinova S.V., Gurviсh V.B., Sutunkova M.P., Katsnelson B.A.


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