TOXICITY UNDER A SINGLE INTRAGASTRIC ADMINISTRATION OF THE ACTIVE CLATHRATE COMPLEX OF β-CYCLODEXTRIN WITH 3-(2-PHENYLETHYL)-2-THIOXO-1,3- THIAZOLIDIN-4-ONE

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Abstract

The clathrate complex of 3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one with β-cyclodextrin in the form of a nanopowder with an average particle size of 40.5 nm, with a wide range of pharmacological properties, was developed for the first time. It belongs to class VI of relatively harmless drugs according to Hodge and to class 5 in accordance with GOST 32644-2014.

About the authors

K. T. Erimbetov

All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition - a branch of the Federal Science Center of Animal Husbandry named after academician L.K. Ernst; Research Center «Park of Active Molecules»

Author for correspondence.
Email: erimbetovkt@mail.ru

Erimbetov Kenes Tagaevich

249013, Kaluga Region

Russian Federation

R. A. Zemlyanoy

All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition - a branch of the Federal Science Center of Animal Husbandry named after academician L.K. Ernst

Email: fake@neicon.ru

Zemlyanoy Ruslan Alexandrovich

249013, Kaluga Region

Russian Federation

E. K. Bondarenko

Research Center «Park of Active Molecules»

Email: bondarenko@pam-alliance.ru

Bondarenko Ekaterina Valer’evna

Obninsk, Kaluga region

Russian Federation

A. Ya. Goncharova

Research Center «Park of Active Molecules»

Email: goncharova@pam-alliance.ru

Goncharova Anna Yakovlevna

Obninsk, Kaluga region

Russian Federation

References

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Copyright (c) 2021 Erimbetov K.T., Zemlyanoy R.A., Bondarenko E.K., Goncharova A.Y.


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