TRANSGENERATIONAL EFFECTS OF VINYL CHLORIDE

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Abstract

The impact of vinyl chloride (inhalation exposure at a mean concentration of 1947 mg/m3 during 5 weeks) on the offspring of exposed male rats and intact female rats was studied. The examination of sexually mature offspring included studying behavior in the open field and DNA damage investigation using brain homogenate with DNAcomet assay. It is revealed an increased orienting-exploratory behavior and decrease in the locomotor activity as well as increased DNA damage in the nervous tissue cells as compared with the control animals group .

About the authors

Ekaterina Aleksandrovna Kapustina

Federal State Budgetary Institution «East-Siberian Scientific Center for Human Ecology», Siberian Branch of the Russian Academy of Medical Sciences

Author for correspondence.
Email: kapustinkaE@yandex.ru

Кандидат медицинских наук, научный сотрудник лаборатории ФГБУ ВСНЦ ЭЧ» СО РАМН, 665827, Иркутская область, г. Ангарск

e-mail: kapustinkaE@yandex.ru

Russian Federation

References

  1. Desrosiers T.A., Herring A.H., Shapira S.K., Hooiveld M., Luben T.J., Herdt-Losavio M.L. et al. Paternal occupation and birth defects findings from the National Birth Defects Prevention Study. Occup. Environ. Med. 2012; 69 (8): 534-542.
  2. Pino-Lopez M., Romero-Ayuso D.M. Parental occupational exposures and autism spectrum disorder in children. Rev. Esp. Salud. Publica. 2013; 87 (1): 73-85.
  3. Brandt-Rauf P. W., Li Y., Lonq C., Monaco R., Kovvali G., Marion M.J. Plastics and carcinogenesis: The example of vinyl chloride. J. Carcinog. 2012; 11 (5): 5-8.
  4. Mutlu E., Collins L.B., Stout M.D., Upton P.B., Dave L.B., Winsett D. Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adductN(2),3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC. Chem. Res. Toxicol. 2010; 23 (9): 1485-14
  5. Qiu Y.L., Wang W., Wang T., Liu J., Sun P., Qian J. Genetic polymorphisms, messenger RNA expression of p53, p21 and CCND1 and possible links with chromosomal aberrations in Chinese vinyl chloride-exposed workers. Cancer Epidemiol. Biomarkers Prev. 2008; 17 (10): 2578-2584.
  6. Sanotskiy I.V., Davtyan R.M., Glushchenko V.I. Study of male reproductive function under the action of certain chemicals. Gigiena truda i professional’nye zabolevaniya. 1980; 5: 28-31 (in Russian).
  7. Kurlyandskiy B.A., Stovbur N.N., Dukhovnaya A.I. Probabilistic assessment of the relative sensitivity of the body’s systems to vinyl chloride poisoning. Gigiena i sanitariya. 1978; 8: 51-55 (in Russian).
  8. Wang X.X., Xiao J.W., Meng H.L., Cui T., Niu K.L., Li B. Effect of vinyl chloride on reproductive and endocrine system of male rats. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010; 28 (7): 517-520.
  9. Lang S.M., Uilson R.P. Lab rat. Labora-tornye zhivotnye. 1993; 2: 101-110 (in Russian).
  10. Samotrueva M.A., Teplyy D.L., Tyurenkov I.N. Experimental models of behavior. Estestvennye nauki. 2009; 2: 140-152 (in Russian).
  11. Durnev A.D., Zhanataev A.K., Anisina E.A., Sidneva E.S., Nikitina V.A., Ogane-syants L.A. et al. Application of alkaline gel electrophoresis of isolated cells to assess the genotoxic properties of natural and synthetic compounds. Moscow; 2006 (in Russian).
  12. Borovskaya T.G., Shchemerova Yu.F., Gol’dberg V.E. Condition offspring of male rats treated with inhibitors of topoisomerase. Sibirskiy onkologicheskiy zhurnal. 2006; 4:33-36 (in Russian).
  13. Dogliotti E. Molecular mechanisms of carcinogenesis by vinyl chloride. Ann Ist Super Sanita. 2006; 42 (2): 163-169.
  14. Giri A.K. Genetic toxicology of vinyl chloride-a review. Mutat. Res. 1995; 339 (1): 1-14.
  15. Brevik A., Lindeman B., Rusnakova V., Olsen A.K., Brunborg G., Duale N. Paternal benzo[a]pyrene exposure affects gene expression in the early developing mouse embryo. Toxicol. Sci. 2012; 129 (1):157-1
  16. Grenier L., Robaire B., Hales B.F. Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division. PLoS One. 2011; 6 (11): e27600.

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