FUNCTIONAL PARAMETERS OF ISOLATED RAT MYOCARDIUM AFTER THE COURSE OF DIOCTYL TEREPHTHALATE

The cardiotoxic effect of long-term (within 60 days) inhalation of dioctyl terephthalate at doses of 3,4; 18,6 and 96.8  mg/m³ has been studied on a model of isolated rat heart. The course administration of dioctyl terephthalate does not change the contractile activity and adrenoreactivity of the rat heart. Dioctyl terephthalate at doses of 96.8              mg/m³ and 18,6 mg/m³ contributes to the development of changes in the electrical activity of the myocardium, leading to an increase in the amplitude of the R and T waves, lengthening the QT interval and shortening the PR interval, which can cause cardiac arrhythmias in ischemic conditions. Adrenoreactivity of isolated heart does not change under the influence of dioctyl terephthalate. The data obtained indicate that the dioctyl terephthalate at concentration of 3,4 mg/m3 is safe for heart.