Мақаланы E-mail арқылы жіберу EXPERIMENTAL EVALUATION OF TOXICOMETRIC INDICATORS AND ANALGESIC ACTIVITY OF KAPPA-OPIOID RECEPTOR AGONISTS
- Авторлар: Chepur S.V.1, Galan S.E.1, Vakhviayanen M.S.1, Khromov R.N.1, Semenov A.N.1
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Мекемелер:
- State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
- Шығарылым: № 4 (2020)
- Беттер: 27-33
- Бөлім: Articles
- ##submission.datePublished##: 31.07.2020
- URL: https://vestnik.nvsu.ru/0869-7922/article/view/641248
- DOI: https://doi.org/10.36946/0869-7922-2020-4-27-33
- ID: 641248
Дәйексөз келтіру
Толық мәтін
Аннотация
Data on the biological activity of kappa-opioid receptor agonists - derivatives of three groups of compounds: 1,2-cyclohexylamine, 1,2,3,4-piperidine, 1,2,4-piperazine are presented. On the examples of 1,2-cyclohexylamine and 1,2,4-piperazine derivatives, it has been shown that a decrease in the length of the carbon chain in the phenylalkyl substituent at the nitrogen atom is accompanied by a decrease in the analgesic activity and toxicity of compounds. The replacement of chlorine atoms in the 3 and 4 positions of the phenyl ring with fluorine atoms, which are more electronegative, leads to an increase in the analgesic effect and a decrease in the toxicity of the compounds.
Авторлар туралы
S. Chepur
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Хат алмасуға жауапты Автор.
Email: gniiivm_15@mil.ru
Chepur Sergei Viktorovich
195043, Saint Petersburg
РесейS. Galan
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Email: gniiivm_15@mil.ru
Galan Sergei Evgenievich
195043, Saint Petersburg
РесейM. Vakhviayanen
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Email: gniiivm_15@mil.ru
Vakhviayanen Maria Sergeevna
195043, Saint Petersburg
РесейR. Khromov
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Email: gniiivm_15@mil.ru
Khromov Roman Nikolaevich
195043, Saint Petersburg
РесейA. Semenov
State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation
Email: gniiivm_15@mil.ru
Semenov Alexander Nikolaevich
195043, Saint Petersburg
РесейӘдебиет тізімі
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