Glushkovskaya EFFECT OF CHEMICAL FACTORS AND LIGHT STRESS ON BLOOD PARAMETERS OF LABORATORY ANIMALS

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Individual and combined effects of sodium nitrite and amine (p-toluidine) including additional light stress conditions on laboratory mice were investigated. It has been established that the physical impact (light stress) for 107 days causes a significant increase in serum alanine aminotransferase activity and decrease of gammaglutamyltransferase activity in laboratory mice. A slight increase in the studied parameters of protein metabolism (urea and creatinine) in mice exposed to light stress was observed. Under exposure additional to chemical stress (enteral injection of a combination of sodium nitrite and p-toluidine), the activity of the enzymes indicator in serum increases: alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. A decrease in the activity of gamma-glutamyl transferase under combined action of stress conditions of various nature compared to the control was found. The observed effects of stress factors on the enzyme activity of blood serum correlate with pathomorphological changes in the esophagus and stomach.

Sobre autores

Е. Pleshakova

N.G. Chernyshevsky Saratov State University

Autor responsável pela correspondência
Email: noemail@neicon.ru
Rússia

M. Kanevskiy

N.G. Chernyshevsky Saratov State University

Email: noemail@neicon.ru
Rússia

S. Yulaeva

Ltd «Medical and Diagnostic Center» Avesta»

Email: noemail@neicon.ru
Rússia

A. Galitskaya

N.G. Chernyshevsky Saratov State University

Email: noemail@neicon.ru
Rússia

S. Konnova

N.G. Chernyshevsky Saratov State University

Email: noemail@neicon.ru
Rússia

O. Semyachkina-

N.G. Chernyshevsky Saratov State University

Email: noemail@neicon.ru
Rússia

Bibliografia

  1. Compare D., Rocco A., Nardone G. Risk factors in gastric cancer. European Review for Medical and Pharmacological Sciences. 2010; 14: 302-308.
  2. Wei-Hua Jia, Xiang-Yu Luo, Bing-Jian Feng, Hong-Lian Ruan, Jin-Xin Bei, WenSheng Liu et al. Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, China. BMC Cancer. 2010; 10: 446-452.
  3. Jakszyn P., González C.A. Nitrosamine and related food intake and gastric and oesophageal cancer risk: A systematic review of the epidemiological evidence. World J Gastroenterol. 2006; 12 (27): 4296-4303.
  4. Ozdestan Ö., Üren A. Nitrate and nitrite contents of baby foods. Akademik Gıda. 2012; 10 (4): 11-18.
  5. Hord N.G., Tang Y., Bryan N.S. Food sources of nitrates and nitrites: The physiologic context for potential health benefits. Am. J. Clin. Nutr. 2009; 90: 1-10.
  6. Mensinga T.T., Speijers G.J., Meulenbelt J. Health implications of exposure to environmental nitrogenous compounds. Toxicol. Rev. 2003; 22: 41-51.
  7. Greenblatt M., Mirvish S., So B.T. Nitrosamine studies: induction of lung adenomas by concurrent administration of sodium nitrite and secondary amines in Swiss mice. J. Natl. Cancer Inst. 1971; 46: 1029-1034.
  8. IPCS; Poisons Information Monograph G016: Nitrates and nitrites. (September 1996). Available from, as of October 24, 2006: http://www. inchem. org/ documents/pims/chemical/pimg016. html.
  9. Евдокимова О.В., Городецкая И.В. Влияние экспериментального гипотиреоза и малых доз l-тироксина на активность аминотрансфераз и гамма-глутамилтрансферазы в крови при действии стрессоров различного происхождения. Вестник Витебского государственного медицинского университета. 2013; 12 (4): 33-43.
  10. Назаренко Г.И., Кишкун А.А. Клиническая оценка результатов лабораторных исследований. М.: Медицина, 20
  11. Koner B.C., Banerjee B.D., Ray A. Effects of stress on gamma glutamyltranspeptidase (GGT) activity in lymphoid system of rats: modulation by drugs. Indian J Exp Biol. 1997; 35 (3): 222-224.
  12. Нарымбетова Т.М., Жуманазаров Н.А., Ишигов И.А., Асанова Г.Н., Мустафаева А.А., Кувандикова Ф.М. Структурные изменения слизистой оболочки желудка при экспериментальной гипокинезии. Успехи современного естествознания. 2011; 6. С. 20-26.

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Declaração de direitos autorais © Pleshakova Е.V., Kanevskiy M.V., Yulaeva S.I., Galitskaya A.A., Konnova S.А., Semyachkina- O.V., 2016


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