THE STUDY OF ATROPINE EFFECT ON THE BLOOD ESTERASE STATUS IN RATS AT DIFFERENT WAYS OF UPTAKE OF MALATHION BY THE ORGANISM

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The therapeutic action of atropine (0.4, 2, 20 mg/kg) was assessed on models of rats intramuscular and intragastric poisoning with malathion in a dose of 1 LD50. It was demonstrated that the drug prevented animals death after the intramuscular administration of malathion and promoted the reduction of intensity of a cholinopositive symptomatology. It also promoted the recovery of the acetyl cholinesterase activity in rats blood up to 80% 8 hours after the therapy, and 24 hours after the injection of malathion, this index reached levels in the control group. The preparation had no protective effect on the modelled intragastric poisoning by malathion independently of its dose. In animals to which atropine (2mg/kg) was administrated an hour after intoxication, the enzyme activity in blood was 40% while in the control group it was 80%. It is practicable to take these findings into consideration while searching and selecting efficient medications for emergency treatment of organophosphorous intoxications.

作者简介

Mikhail Yudin

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy, Ministry of Defense

编辑信件的主要联系方式.
Email: noemail@neicon.ru

Кандидат медицинских наук, доцент, заместитель начальника отдела НИИИ (ВМ) ВМедА им. С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация

e-mail: mihei_bridge@mail.ru

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Vladimir Bykov

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy, Ministry of Defense

Email: noemail@neicon.ru

Доктор медицинских наук, профессор, начальник НИИЦ (МБЗ) НИИИ (ВМ) ВМедА им. С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация

e-mail: ykov_imm@mail.ru

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Alexandr Kolesnikov

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy, Ministry of Defense

Email: noemail@neicon.ru

Лаборант-исследователь НИИИ (ВМ) ВМедА им. С.М. Кирова, 195043, г. СанктПетербург, Российская Федерация

 e-mail: Alex9_6_89@mail.ru 

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Andrey Sarana

City Hospital № 40

Email: noemail@neicon.ru

Кандидат медицинских наук, доцент, заместитель главного врача по реабилитации СПб ГБУЗ «Городская больница № 40», главный специалист по медицинской реабилитации и санитарно-курортному делу Комитета по Здравоохранению
правительства г. Санкт-Петербурга, 197706, г. Сестрорецк, г. Санкт-Петербург, Российская Федерация 

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Il’ya Yudnikov

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy, Ministry of Defense

Email: noemail@neicon.ru

Научный сотрудник НИИИ (ВМ) ВМедА им. С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация 

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参考

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版权所有 © Yudin M.A., Bykov V.N., Kolesnikov A.M., Sarana A.M., Yudnikov I.V., 2015


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