ASSOCIATION OF LOWER URINARY TRACT SYMPTOMS AND TESTOSTERONE DEFICIENCY IN MEN WITH TYPE 2 DIABETES


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Abstract

Introduction & Objectives. Type 2 diabetes mellitus, as a chronic systemic metabolic disease, is widely spread in the population of middle-aged men. Previously it has been proven the link between the presence of type 2 diabetes and the development of lower urinary tract symptoms in men. At the same time, middle-aged men are characterized by the appearance and progression of benign prostatic hyperplasia. Material & Methods. We performed a study of middle-aged men with type 2 diabetes to determine the interrelation of micturition disorders with deficiency of serum testosterone, in respect that the pathophysiology of prostatic hyperplasia is regarded as dysmetabolic dyshormonal state. The prospective study examined 112 men with type 2 diabetes randomized by the level of total testosterone. Lower urinary tract symptoms were assessed by I-PSS questionnaire. The study of serum total PSA, uroflowmetry, transrectal prostate ultrasonography were performed. Results. As a result of the study the association between the severity of type 2 diabetes mellitus and the decrease in total testosterone levels was determined. The relationship of testosterone deficiency and the frequency of the presence and severity of lower urinary tract symptoms were demonstrated. The dependence of the prostate hyperplasia risks progression with the level of serum testosterone was found. Conclusions. The association of testosterone deficiency with frequency and severity of lower urinary tract symptoms, partially related with benign prostatic hyperplasia and clinically defined detrusor cistopathy, has been proven. Further clinical studies are needed to determine the pathophysiological and pathomorphological features of type 2 diabetes, which determines the development of detrusor cistopathy and late onset hypigonadism.

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About the authors

M. I Kogan

Rostov State Medical University

Email: dept_kogan@mail.ru
Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists

I. I Belousov

Rostov State Medical University

Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists

H. S Ibishev

Rostov State Medical University

Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists

A. A Cherniy

Rostov State Medical University

Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists

I. A Khripun

Rostov State Medical University

Department of Endocrinology with the course Pediatric Endocrinology Faculty training and retraining of specialists

S. V Vorobyev

Rostov State Medical University

Department of Endocrinology with the course Pediatric Endocrinology Faculty training and retraining of specialists

D. V Sizaykin

Rostov State Medical University

Department of Urology and reproductive health with the course of Pediatric Urology-Andrology. Faculty training and retraining of specialists

References

  1. Centers for Disease Control and Prevention. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States. US Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, 2011.
  2. Xu Y., Wang L., He J., Bi Y., Li M., Wang T., Wang L., Jiang Y., Dai M., Lu J., Xu M., Li Y., Hu N, Li J., Mi S., Chen C.S., Li G., Mu Y., Zhao J., Kong L., Chen J., Lai S., Wang W., Zhao W., Ning G; 2010 China Noncommunicable Disease Surveillance Group. Prevalence and control of diabetes in Chinese adults. JAMA. 2013;310:948-959.
  3. American Diabetes Association. Economic costs of diabetes in the U.S. in 2012. Diabetes Care. 2013;36:1033-1046.
  4. Данные ВОЗ по диабету. http://www.who.int/topics/diabetes mellitus/ru/
  5. Jordan W.F., Crabtree H.H. Paralysis of the bladder in diabetic patients. Arch Int Med. 1935;55:17-25.
  6. Пушкарь Д.Ю., Раснер П.И., Харчилава Р.Р. Симптомы нижних мочевыводящих путей и доброкачественная гиперплазия предстательной железы. Урология. 2016; 2 (приложение 2): 4-19.
  7. Спивак Л.Г., Локшин К.Л., Винаров А.З. Обзор клинических исследований комбинированной терапии ингибиторами 5а-редуктазы и а1-адреноблокаторами пациентов с гиперплазией предстательной железы. Урология. 2015;4:125- 133.
  8. Mangera A., Chapple Ch. Научно обоснованное обновление рекомендаций по обследованию и лечению мужчин с симптомами нижних мочевыводящих путей. Урология. 2015;2:94-102.
  9. Morgentaler A., Zitzmann M., Traish A.M., Fox A.W., Jones T.H., Maggi M., Arver S., Aversa A., Chan J.C., Dobs A.S., Hackett G.I., Hellstrom W.J., Lim P., Lunenfeld B., Mskhalaya G., Schulman C.C., Torres L.O. Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Consensus Resolutions. Mayo Clin Proc. 2016;91(7):881-896.
  10. Коган М.И., Белоусов И.И., Ибишев Х.С., Воробьев С.В., Хрипун И.А., Сизякин Д.В., Черный А.А., Моргунов М.Н., Паленый А.В. Особенности эректильной дисфункции при сахарном диабете 2 типа и дефиците сывороточного тестостерона. Урология. 2015;6:87-92.
  11. Morales A., Bella A., Chun S., Lee J. A practical guide to diagnosis, management and treatment of testosterone deficiency for Canadian physicians. Can Urol Assoc J. 2010;4(4): 269-275.
  12. Yassin A., Saad F., Haider A., Gooren L. The role of the urologist in the prevention and early detection of cardiovascular disease. Arab J Urology. 2011; 9: 57-62.
  13. Saghier E., Shebl S., Fawzy O., Eltayeb I., Bekhet L., Gharib A. Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes. Clin Med Insights Endocrinol Diabetes. 2015;8:55-62.
  14. Mitteness L.S. Knowledge and beliefs about urinary incontinence in adulthood and old age. J Am Geriatr Soc. 1990;38:374-378.
  15. Brown J.S., Wessells H., Chancellor M.B., Howards S.S., Stamm W.E., Stapleton A.E., Steers W.D., Van Den Eeden S.K., McVary K.T. Urologie complications of diabetes. Diabetes Care. 2005; 28: 177185.
  16. Jordan W.F., Crabtree H.H. Paralysis of the bladder in diabetic patients. Arch Int Med. 1935; 55: 17-25.
  17. Lee W.C, Wu H.P., Tai T.Y., Liu S.P., Chen J, Yu H.J. Effects of diabetes on female voiding behavior. J Urol. 2004; 172: 989-992.
  18. Liu R.T., Chung M.S., Lee W.C., Chang S.W., Huang S.T., Yang K.D., Chancellor M.B., Chuang Y.C. Prevalence of overactive bladder and associated risk factors in 1359 patients with type 2 diabetes. Urology. 2011;78:1040-1045.

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