ANTIDIABETIC EFFECT OF A NEW ORIGINAL NT-3 DIPEPTIDE MIMETIC

S. S. Yagubova; Ягубова С. С.; M. A. Chernyshevskaya; Чернышевская М. А.; R. U. Ostrovskaya; Островская Р. У.; T. A. Gudasheva; Гудашева Т. А.; S. B. Seredenin; Середенин С. Б.

doi:10.31857/S2686738923700336

ANTIDIABETIC EFFECT OF A NEW ORIGINAL NT-3 DIPEPTIDE MIMETIC

Authors: Yagubova S.S.¹, Chernyshevskaya M.A.¹, Ostrovskaya R.U.¹, Gudasheva T.A.¹, Seredenin S.B.¹
Affiliations:
1. Federal State Budgetary Institution “Research Zakusov Institue of Pharmacology”
Issue: Vol 512, No 1 (2023)
Pages: 417-421
Section: Articles
URL: https://vestnik.nvsu.ru/2686-7389/article/view/651065
DOI: https://doi.org/10.31857/S2686738923700336
EDN: https://elibrary.ru/PUTHWA
ID: 651065

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Abstract

It was previously established that the original dipeptide mimetic of the 4th loop of NT-3, hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301), has a pronounced neuroprotective effect in vitro at concentrations of 10^–5–10^–12 М. In the present study, experiments on the streptozotocin-induced diabetes model in C57Bl/6 mice showed that GTS-301, administered intraperitoneally for 32 days at doses of 0.1 and 0.5 mg/kg, has antidiabetic activity manifested in the reduction of hyperglycemia, polydipsia, and in the increase of animal survival. The results obtained confirm the concept of the similarity of neurochemical mechanisms underlying the regulation of neurons and β-cells functions.

Keywords

NT-3, low-molecular-weight mimetic, dipeptide, GTS-301, streptozotocin, diabetes, antidiabetic activity, C57Bl/6 mice

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