This investigation was conducted to study the psychofunctional status of male respondents of working age who are under the combined influence of adverse environment such as socio-natural conditions. According to the results obtained, in groups of men working in a northern region at a security company in aperiodic shift mode, hemodynamic parameters differed depending on seniority: among people with more than 5 years of work experience systolic BP values were higher and there was a strong tendency to higher diastolic and pulse BP. A lower vascular tone was noted among male students of the Northern Medical University, which indicates a lower activity of the sympathetic department of the autonomic nervous system. Their magnitude of systolic blood pressure approached the data of men with greater work experience. According to the results of the WAM methodology (well-being, activity, mood), in all three scales, the psychofunctional status of employees with less work experience was more favorable. Their self-assessment in the scales of well-being and activity differed greately. In comparison with the guards of both groups, students demonstrated a more favorable psychofunctional state in the scales of well-being and mood during the intersessional period. In accordance with the activity indicators, they were inferior to men whose work experience was less than 5 years. As a result, the formation of negative trends in hemodynamics was revealed among men with longer labor experience. It was most pronounced in the indicators of the heart component of blood pressure – systolic blood pressure. In the group of students, the average characteristics of the systolic blood pressure were approaching the data of a group of men with greater work experience. With an increase of work experience, self-assessment of psychofunctional status is reduced, especially in the scale of well-being. According to the activity scale, students were inferior to men whose work experience was less than 5 years. The results of the study demonstrate stress factors that distinguish the educational process of a northern medical university. Their impact is comparable to the consequences of aperiodic work in shifts with a high level of psychoemotional stress. In the north, these influences are aggravated by complex climatogeophysical conditions.