The purpose of this study was to study the influence of the variability of weather and heliophysical factors on the appeal to the “Ambulance” service for different groups of nosologies in the population of the Russian North. Information about calls to the emergency medical service of Khanty-Mansiysk was obtained from the database of calls for the period from 2001 to 2021 by disease classes (ICD-10). To assess the dynamics of weather factors, data from the All-Russian Research Institute of Hydrometeorological Information and materials from the weather station of Khanty-Mansiysk were used. The dynamics of air temperature; barometric pressure; relative humidity; baric trend; maximum wind speed; weight oxygen content in the air are analyzed. Data on the relative daily number of sunspots are obtained from the materials of the Royal Observatory of Belgium. The average daily values of the level of planetary geomagnetic activity, expressed by the Ap index, are copied from the website of the National Center for Geophysical Data of the USA (Boulder). Mathematical processing was carried out using wavelet analysis. The graph of temperature fluctuations for the period from 2001 to 2021 shows a significant circadian cyclicity and a semi-annual rhythm with a high level of trend. Significant rhythms of barometric pressure with a period of 5 years, 1 year and rhythms close to semi-annual, seasonal and near-monthly are observed. Humidity changes significantly in the circadian and intra-annual rhythms. The baric tendency has significant rhythms: 3 years, 1 year, 6, 3, 2 months. Changes in the maximum wind speed do not have a circadian rhythm, but intra-annual monthly variations are observed. The value of the weight oxygen content has circadian; two-year, five-year; two- and near-monthly rhythms. The relative number of sunspots (W) for the period from 2001 to 2021 is characterized by a five-, two-year and circadian rhythm. When considering the variations of the number W for the period from 1818 to 2017, in addition to the classic eleven-year, annual and near-monthly, rhythms with a period of 42.5 years, 18.1 years and 2.1 years are found. The index of planetary geomagnetic activity (Ar) has a rhythm with a period of 4 years, two-year and near-annual. The significance of all rhythms is p=0.001. When analyzing fluctuations in geomagnetic activity from 1932 to 2016, long-term rhythms are added: 35.00 years; 16.06 years; 10.88 years; semi-annual and three-month rhythms. Despite numerous hypotheses of the search for cosmobiological harmony in the form of “evolutionary synchronisms”, “rhythmic cascades”, “golden section”, the problem of the interaction of exogenous natural rhythms and endogenous rhythms of the human body remains largely unresolved. Comparison of the results of various studies is difficult due to methodological and mathematical approaches. With observation periods of 100-200 years or more, a long-period component is monitored, and in clinical studies (from a day to a week), short-period components are detected. Changing the background in the form of helioclimatic and social variations also does not add accuracy. The use of various methods of time series analysis involves obtaining information of different resolution levels (Fourier transform, SWANN, wavelet analysis). Nevertheless, the results obtained track the classical rhythms of solar and geomagnetic activity with periods of about eleven years, a year and a month. There is also a 35-year-old rhythm, a 42.5-year-old rhythm close to the 44.16-year rhythm identified by Bezrukova A.Ya., at 18.1 years (long-period components of the lunar tide) and other intra-annual rhythms with periods from two weeks to 9 months. The effect of helioclimatic factors on human health indicates the absence of constant coherence (in our case, the consistency of these processes over time, manifested when they are combined), due to the presence of a large number of mega- and mesorhythms, which is manifested by amplitude and phase desynchronization of heliogeophysical indicators and health status.