The relevance of the study is due to the fact that qualitative changes in military professional activity necessitate high-quality professional training of future military specialists capable of manifesting professional responsibility in the context of constantly changing social and military practices. The purpose of the article is to present the results of a study demonstrating the psychological and pedagogical potential of the relationship between reflexivity and life-meaning orientations in the formation of professional responsibility in future military specialists. To obtain empirical data, the technique for determining the level of reflexivity by A.V. Karpova, a test of life-meaning orientations (in the adaptation of D.A. Leontiev), and also mathematical and statistical methods of data processing. In the course of the study, the interrelation of reflexivity and life-meaning orientations of future military specialists was revealed, which provides an assessment of the productivity of a lived segment of life, the degree of comprehension of prospects and direction of actions; developing the ability to control behavior in professional and life situations; awareness of freedom of choice in accordance with the goals set, understanding of responsibility for the successes and failures in their activities, due to its capabilities. The methodological support of the formation of professional responsibility of future military specialists on the basis of the relationship between reflexivity and life-meaning orientations has been determined, which includes: reflexive seminars aimed at the development of self-governing personality mechanisms; the use of situational tasks as a methodological technique that imitates a practically significant professional situation; the method of projects, which allows to apply in practice the intellectual resources of the student, to form teamwork skills and responsibility for the result in the conditions of educational and professional activities; organization of research activities, providing search and research activity in relation to non-standard professional tasks. The productivity of the influence of the interrelation of reflection and the peculiarities of life-meaning orientations on the formation of professional responsibility of future military specialists has been confirmed.