The paper presents the data on the adaptive features of healthy and meteotropic women, including new residents of the Northen regions and returnees. The authors evaluated the quality of life using SF-36 questionnaire. The analysis showed rather negative physiological and somatic values in all groups, including meteotropic women and returnees, in particular. Women of the senior group had the largest number of risk factors (17 out of 21), most important of which included cold weather, temperature and air pressure variations, solar magnetic perturbations, dyspnea, smoking, fatigue and excess body weight. The analysis of non-specific resistance reactions showed certain extersion of protective features in all groups. We revealed a small number of training responses in all age groups except the group of young women. The group of new settlers with the 1st degree of meteosensitivity showed an increase in the number of training reactions. According to the breath-holding tests, the antihypocsitic stability values were always higher on the inhale than on the exhale. The study revealed negative effects of meteotropy and remigration. Blood tests showed a significantly high anemia occurrence while the level of hemoglobin was close to norm much more often than the number of red blood cells. The levels of non-specific resistance showed a gradual increase in the acute and chronic stress and increased activation reactions in the groups of elderly women, returnees and meteotropicwomen. The study showed quite little number of stress reactions and revealed the fact that the impact of meteorological factors decreases in older age groups and that women showed high sensitive values in the scales of emotions. Non-meteotrophic individuals showed dominant activation reaction in case of stress. As the degree of meteosensitivity increased, it resulted in a shift towards increased activation reaction and increased role of HP in the resistance to weather risk factors.