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The effectiveness of respiratory support in the early period of intoxication of rabbits with products of thermal degradation of fluoroplast-4
- Authors: Tolkach P.G.1, Yaroshenko D.M.1, Khovpachev A.A.1, Sizova D.T.1, Ilatovskaya Y.D.2, Gracheva G.U.2,3, Basharin V.A.1
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Affiliations:
- Kirov Military Medical Academy
- Veterinary clinic of oncology, traumatology and intensive care of Dr. Sotnikov
- St. Petersburg State University of veterinary medicine
- Issue: Vol 144, No 4 (2024)
- Pages: 435-441
- Section: Articles
- Submitted: 02.02.2025
- Published: 22.07.2024
- URL: https://vestnik.nvsu.ru/0042-1324/article/view/653191
- DOI: https://doi.org/10.31857/S0042132424040063
- EDN: https://elibrary.ru/PPEBND
- ID: 653191
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Abstract
Inhalation intoxication with acylating pulmonotoxicants (phosgene, perfluoroisobutylene) leads to the formation of toxic pulmonary edema, pharmacological approaches to the treatment of which are ineffective. Respiratory therapy is successfully used to treat non-toxic pulmonary edema. Data on the effectiveness of respiratory support in toxic pulmonary edema are limited. The aim of the study was to experimentally evaluate the effectiveness of protective ventilation with positive end-expiratory pressure in the early period of intoxication by products of thermal degradation of fluoroplast-4. Early initiation of protective ventilation with positive end-expiratory pressure proved to be effective for the correction of toxic pulmonary edema in rabbits in the early period of intoxication by products of thermal degradation of fluoroplast-4 with pulmonotoxic effects. Respiratory support may be an effective approach for the treatment of toxic pulmonary edema caused by intoxication with acylating pulmonotoxicants.
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About the authors
P. G. Tolkach
Kirov Military Medical Academy
Author for correspondence.
Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg
D. M. Yaroshenko
Kirov Military Medical Academy
Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg
A. A. Khovpachev
Kirov Military Medical Academy
Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg
D. T. Sizova
Kirov Military Medical Academy
Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg
Yu. D. Ilatovskaya
Veterinary clinic of oncology, traumatology and intensive care of Dr. Sotnikov
Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg
G. U. Gracheva
Veterinary clinic of oncology, traumatology and intensive care of Dr. Sotnikov; St. Petersburg State University of veterinary medicine
Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg; St. Petersburg
V. A. Basharin
Kirov Military Medical Academy
Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg
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