ASSESSMENT OF TOXIC ACTION OF VARIOUS TREATMENT REGIMENS FOR TUBERCULOSIS IN PATIENTS WITH HIV INFECTION

The Russian Federation is among the countries with a high burden of tuberculosis and the worsening epidemiological situation of HIV. In patients with HIV infection mortality from TB reaches 43-89%. The incidence of tuberculosis in patients with HIV infection is 21-37 times higher than in people without HIV infection, and in some studies, the risk of developing tuberculosis in the early stages of HIV infection is 113 times higher. The aim of this work is to determine the toxic effect of different treatment regimens for tuberculosis in patients with HIV infection. Patients (total number 200) with tuberculosis and HIV infection with different treatment regimens for tuberculosis were examined. Clinical and laboratory data were studied. It was established that the first standard treatment of tuberculosis had a more pronounced toxic effect on patients, which was manifested by a decrease in appetite, nausea, in some cases vomiting and febrile feverish reaction; had a greater damaging effect on cell membranes, which led to an increase in the activity of alkaline phosphatase and lactate dehydrogenase. However, this regimen of chemotherapy contributes to a reduction in cough with mucus and mucopurulent sputum secretion, dyspnea with physical activity, pain in the chest during breathing that had a more pronounced therapeutic effect. Increase in the level of phosphatidylethanolamine can be considered as a proven marker of the toxic effect of tuberculosis treatment under the first standard regimen.