CHANGES IN THE CHEMICAL COMPOSITION OF BLOOD AND BRAIN OF RATS UNDER THE CONDITIONS OF MODELING OF THE MYELOABLATION REGIMEN OF CYCLOPHOSPHAMIDE ADMINISTRATION

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Abstract

When modeling myeloablation cytostatic chemotherapy with cyclophosphamide in rats fulminant hyperammonemia was observed accompanied by an increase in the content of ammonia and glutamine, a decrease in the content of pyruvic and lactic acids in brain tissue. A positive correlation between the indicators of azotemia and the content of ammonia and glutamine in brain tissue was established. In loading test with ammonium acetate changes in the chemical composition of blood and brain tissue were more pronounced. The data obtained indicate the intensification of the intake of gastrointestinal ammonia into the brain from the blood, which leads to the depletion of the tissue pool of pyruvate with the introduction of cyclophosphane in doses used for myeloablation. Such changes create the conditions for disruption of energy supply of neurological functions during myeloablative cytotoxic chemotherapy using cyclophosphamide.

About the authors

Yu. Yu. Ivnitsky

Institute of Toxicology, Federal Medical Biological Agency

Author for correspondence.
Email: neugierig@mail.ru

Ivnitsky Jury Jurievich

195043, Saint Petersburg

Russian Federation

T. V. Schafer

State Scientific Research Test Institute of the Military Medicine, Ministry of Defense of the Russian Federation

Email: schafer@yandex.ru

Schafer Timur Vasilievich

192019, Saint Petersburg

Russian Federation

A. A. Tyaptin

State Scientific Research Test Institute of the Military Medicine, Ministry of Defense of the Russian Federation

Email: tyaptin@mail.ru

Tyaptin Alexander Andreevich

192019, Saint Petersburg

Russian Federation

V. L. Rejniuk

Institute of Toxicology, Federal Medical Biological Agency

Email: vladton@mail.ru

Rejniuk Vladimir Leonidovich

195043, Saint Petersburg

Russian Federation

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Copyright (c) 2019 Ivnitsky Y.Y., Schafer T.V., Tyaptin A.A., Rejniuk V.L.



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