DIRECT DETERMINATION OF THE CONTENT OF MERCURY AND LEAD IN THE BLOOD OF PREGNANT WOMEN AND THE INFLUENCE OF THEIR LEVEL ON THE TERMINATION OF PREGNANCY IN EARLY TERMS

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Abstract

A methodological approach for the direct determination of mercury in the blood using analyzer RA-915 with pyrolytic decomposition of the sample has been developed. The detection limit of the proposed technique is 0,5 µg/L with the relative standard deviation not exceeding 10%. To determine the lead content, the previously created method of direct lead determination in the blood has been used.
In the second stage of the study, biomonitoring of pregnant women has been carried out in order to identify the relationship between the termination of pregnancy in early terms with the content of mercury and lead in women’s blood. The study involved 25 women with a diagnosis of non-developing pregnancy, and 47 women from the control group.
As a result of the conducted studies, it has been found that the contents of mercury and lead in women with nondeveloping pregnancy were almost 25% higher.

About the authors

E. A. Zubakina

Institute of Toxicology, Federal Medical Biological Agency

Author for correspondence.
Email: mihailova_katya@inbox.ru
192019, Saint Petersburg Russian Federation

N. B. Ivanenko

Institute of Toxicology, Federal Medical Biological Agency

Email: nbivanenko@mail.ru
192019, Saint Petersburg Russian Federation

N. V. Stolyarova

Institute of Toxicology, Federal Medical Biological Agency

Email: snv@toxicology.ru
192019, Saint Petersburg Russian Federation

A. A. Ganeev

Institute of Toxicology, Federal Medical Biological Agency

Email: ganeevaa@lumex.ru
192019, Saint Petersburg Russian Federation

V. A. Каshuro

Institute of Toxicology, Federal Medical Biological Agency

Email: kashuro.v.a@toxicology.ru
192019, Saint Petersburg Russian Federation

D. V. Baibuz

N.I. Pirogov Clinic of High Medical Technologies, Saint Petersburg State University

Email: baybooz@mail.ru
190103, Saint Petersburg Russian Federation

M. M. Bezruchko

Institute of Toxicology, Federal Medical Biological Agency

Email: bezrucko@mail.ru
192019, Saint Petersburg Russian Federation

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Copyright (c) 2019 Zubakina E.A., Ivanenko N.B., Stolyarova N.V., Ganeev A.A., Каshuro V.A., Baibuz D.V., Bezruchko M.M.


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