MANIFESTATIONS OF SUBACUTE SYSTEMIC TOXICITY OF LEAD OXIDE NANOPARTICLES IN RATS AFTER AN INHALATION EXPOSURE

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Abstract

Outbred white female rats were exposed to an aerosol of lead oxide nanoparticles in a nose-only inhalation setup at an average concentration of 1.30 ± 0.10 mg / m3 during 5 days for 4 hours a day. In parallel, the control group of rats was subjected to sham exposure under similar conditions. The deposition of nanoparticles in the lungs and in the olfactory region of the brain was detected using transmission electron microscopy. Some disorders of the body state were detected in the exposed group, some of which can be considered as the result of a lead-specific toxic effect (an increase in the proportion of reticulocytes and in urinary excretion of δ-aminolevulinic acid), and others - the result of nanoparticles circumventing the blood-brain barrier (axon demyelination, vacuolization of the neurons’ cytoplasm).

About the authors

M. Р. Sutunkova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Author for correspondence.
Email: marinasutunkova@yandex.ru

Sutunkova Marina Petrovna

620014, Yekaterinburg

Russian Federation

S. N. Solovyeva

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: solovyevasn@ymrc.ru

Solovyeva Svetlana Nikolaevna

620014, Yekaterinburg

Russian Federation

I. N. Chernyshov

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: chernishov@ymrc.ru

Chernyshov Ivan Nikolaevich

620014, Yekaterinburg

Russian Federation

S. V. Klinova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: klinova.svetlana@gmail.com

Klinova Svetlana Vladislavovna

620014, Yekaterinburg

Russian Federation

V. B. Gurvich

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: gurvich@ymrc.ru

Gurvich Vladimir Borisovich

620014, Yekaterinburg

Russian Federation

V. Ya. Shur

Institute of Natural Sciences, Ural Federal University

Email: vladimir.shur@urfu.ru

Shur Vladimir Yakovlevich

620000, Yekaterinburg

Russian Federation

E. V. Shishkina

Institute of Natural Sciences, Ural Federal University

Email: ekaterina.shishkina@labfer.usu.ru

Shishkina Ekaterina Vladimirovna

620000, Yekaterinburg

Russian Federation

I. V. Zubarev

Institute of Natural Sciences, Ural Federal University

Email: ilyamitozubarev@gmail.com

Zubarev Ilya Vladimirovich

620000, Yekaterinburg

Russian Federation

L. I Privalova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: Privalova@ymrc.ru

Privalova Larisa Ivanovna

620014, Yekaterinburg

Russian Federation

B. A. Katsnelson

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: bkaznelson@etel.ru

Katsnelson Boris Alexandrovich

620014, Yekaterinburg

Russian Federation

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Copyright (c) 2021 Sutunkova M.Р., Solovyeva S.N., Chernyshov I.N., Klinova S.V., Gurvich V.B., Shur V.Y., Shishkina E.V., Zubarev I.V., Privalova L.I., Katsnelson B.A.


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