EXPERIMENTAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF OXYMETHYLURACIL IN COMBINATION WITH KNOWN MEDICINES (MEXIDOL, TONAROL, ACETYLCYSTEINE)

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Abstract

The article presents the results of morphological changes in the liver of rats after acute liver injury induced by carbon tetrachloride and prophylactic correction of injuries by combinations of oxymethyluracil with different types of medical products: «Mexidol», «Tonarol» and Acetylcysteine. The best corrective effect was established after applying a combination of oxymethyluracil with «Tonarol». Thus, according to the results obtained, the studied drugs combinations can be arranged in the following sequence in accordance with decreasing of hepatoprotective activity: OMU / «Tonarol» > OMU / Acetylcysteine> OMU / «Mexidol».

About the authors

Е. F. Repina

Ufa Institute of Occupational Health and Human Ecology

Author for correspondence.
Email: e.f.repina@bk.ru

Repina El’vira Faridovna

450106, Ufa

Russian Federation

D. O. Karimov

Ufa Institute of Occupational Health and Human Ecology

Email: karimovdo@gmail.com

Karimov Denis Olegovich

450106, Ufa

Russian Federation

G. V. Timasheva

Ufa Institute of Occupational Health and Human Ecology

Email: e.f.repina@bk.ru

Timasheva Gul’nara Vil’evna

450106, Ufa

Russian Federation

N. Yu. Khusnutdinova

Ufa Institute of Occupational Health and Human Ecology

Email: h-n-yu@yandex.ru

Khusnutdinova Nadezhda Yurevna

450106, Ufa

Russian Federation

L. A. Musina

All-Russian Centre of Eye and Plastic Surgery of the Russian Health Ministry

Email: morphoplant@mail.ru

Musina Lyalya Akhiyarovna

450075, Ufa

Russian Federation

A. R. Gimadieva

Ufa Institute of Chemistry UFIC RAS

Email: alf_gim@mail.ru

Gimadieva Al’fiya Raisovna

450054, Ufa

Russian Federation

S. S. Baigildin

Ufa Institute of Occupational Health and Human Ecology; Bashkir State University

Email: baigildin.samat@yandex.ru

Baigildin Samat Sagadatovich

450106, Ufa

 

Russian Federation

D. A. Smolyankin

Ufa Institute of Occupational Health and Human Ecology

Email: smolyankin.denis@yandex.ru

Smolyankin Denis Anatol’evich

450106, Ufa

Russian Federation

Ya. V. Valova

Ufa Institute of Occupational Health and Human Ecology

Email: q.juk@ya.ru

Valova Yana Valer’evna

450106, Ufa

Russian Federation

References

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Copyright (c) 2021 Repina Е.F., Karimov D.O., Timasheva G.V., Khusnutdinova N.Y., Musina L.A., Gimadieva A.R., Baigildin S.S., Smolyankin D.A., Valova Y.V.


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