MORPHOLOGICAL PECULIARITIES OF THE ACTION OF PEPTIDE DRUGS AT ACUTE POISONING WITH ETHYL ALCOHOL IN EXPERIMENT

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Abstract

Results of an investigation into liver morphological changes at acute poisoning with ethyl alcohol and their correction with molixan and semax combination are presented. Ethanol was administrated intragastrically as a 40% solution in a dose of 12 g/kg that corresponds to 1.5 LD50. Semax was administrated intranasally in a dose of 3 mg/kg and molixan intraabdominally in a dose of 30 mg/kg. The preparations efficacy was evaluated using the following application schemes: prophylactic (single dose an hour prior to ethanol), therapeutic and prophylactic (an hour before and just after administration of ethanol), early therapeutic (just after administration of ethanol and then once daily during two next days) and delayed therapeutic (30 min after administration of ethanol and then once daily during two next days). The sampling of the material under investigation was performed 1 hour, 3 hours, 1 day and 3 days after modelling of the alcohol intoxication. It was found out that ethanol in a dose of 1.5 LD50 induces changes in liver in the form of fatty, albuminous, hydropic degeneration, focal necrosis, stromal cell reactions. It was shown that the therapeutic and prophylactic application of the molixan and semax combination significantly reduces the intensity and prevalence of dystrophic and necrotic processes and stromal cell reactions in liver.

About the authors

Denis Aleksandrovich Halyutin

Federal State Budgetary Military Educational Establishment of Higher Professional Education «S.M. Kirov Military Medical Academy», RF Ministry of Defense

Author for correspondence.
Email: noemail@neicon.ru

Аъюнкт при кафедре военной токсикологии и медицинской защиты Военно-медицинской академии имени С.М. Кирова МО РФ, г. Санкт-Петербург, Российская Федерация

e-mail: hal-denis81@yandex.ru

Russian Federation

Tatyana Semenovna Solovyeva

Federal State Budgetary Military Educational Establishment of Higher Professional Education «S.M. Kirov Military Medical Academy», RF Ministry of Defense

Email: noemail@neicon.ru

Кандидат медицинских наук, доцент кафедры патологической анатомии Военно-медицинской академии имени С.М. Кирова МО РФ, г. Санкт-Петербург, Российская Федерация

e-mail: soloveva70@list.ru

Russian Federation

Vadim Semenovich Czerski

Federal State Budgetary Military Educational Establishment of Higher Professional Education «S.M. Kirov Military Medical Academy», RF Ministry of Defense

Email: noemail@neicon.ru

Доктор медицинских наук, начальник кафедры патологической анатомии Военно-медицинской академии имени С.М. Кирова МО РФ, г. Санкт-Петербург, начальник Центральной патологоанатомической лаборатории (МО РФ) — главный
патологоанатом МО РФ, Российская Федерация

e-mail: czerski@mail.ru

Russian Federation

Vladimir Leonidovich Reiniuk

Federal State Budgetary Military Educational Establishment of Higher Professional Education «S.M. Kirov Military Medical Academy», RF Ministry of Defense

Email: noemail@neicon.ru

Доктор медицинских наук доцент, профессор кафедры военной токсикологии и медицинской защиты Военно-медицинской академии имени С.М. Кирова МО РФ, г. Санкт-Петербург, Российская Федерация

e-mail: vladton@mail.ru

Russian Federation

Aleksandr Evgenyevich Antushevich

Federal State Budgetary Military Educational Establishment of Higher Professional Education «S.M. Kirov Military Medical Academy», RF Ministry of Defense

Email: noemail@neicon.ru

Доктор медицинских наук, профессор, старший научный сотрудник научно-исследовательской лаборатории военной терапии научно-исследовательского центра Военно-медицинской академии имени С.М. Кирова МО РФ,
г. Санкт-Петербург, Российская Федерация

e-mail: mantushevich@mail.ru 

Russian Federation

Aleksandr Nikolaevich Grebenyuk

Federal State Budgetary Military Educational Establishment of Higher Professional Education «S.M. Kirov Military Medical Academy», RF Ministry of Defense

Email: noemail@neicon.ru

Доктор медицинских наук, профессор, профессор кафедры военной токсикологии и медицинской защиты Военно-медицинской академии имени С.М. Кирова МО РФ, г. Санкт-Петербург, Российская Федерация

e-mail: grebenyuk_an@mail.ru

Russian Federation

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Copyright (c) 2015 Halyutin D.A., Solovyeva T.S., Czerski V.S., Reiniuk V.L., Antushevich A.E., Grebenyuk A.N.


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