ASSOCIATION OF BCHE GENE POLYMORPHIC VARIANTS WITH BUTYRYLCHOLINESTERASE ACTIVITY IN RATS POISONED WITH MALATHION

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The association of Bche gene polymorphisms with butyrylcholinesterase activity was investigated on a model of rats poisoned with malathion at a dose of 1 LD50. The genotype distribution of six polymorphic variants of Bche gene was studied. An authentic association (p C (SNPID rs198598583), G>T (SNPID rs106118718), A>T (SNPID rs107226860) with butyrylcholinesterase activity in the liver tissue a day after poisoning was shown; the prevalence of those polymorphic variants is associated with linked type of inheritance. The highest linkage correlation of the enzyme activity in the liver was observed in variants A>T (rs107226860) and G>T (rs106118718). Enzyme activity in rats with a homozygous genotype was authentically higher ( by 30%) compared to the heterozygous genotype.

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Aleksandr Babkin

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

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Научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: babkinnik@yandex.ru

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Irina Berdinskih

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: irina_berdinskih@mail.ru

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Natalya Osechkina

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

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Младший научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: dunats@rambler.ru

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Georgiy Nazarov

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Доктор химических наук, доцент, начальник отдела НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург,

e-mail: denis-100@list.ru

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Mikhail Judin

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Кандидат медицинских наук, доцент, заместитель начальника отдела НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: mikhail.judin@gmail.com

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Vladimir Bykov

Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy

Email: noemail@neicon.ru

Доктор медицинских наук, доцент, начальник центра НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург

e-mail: bykov_imm@yahoo.com

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Andrey Sarana

City Hospital № 40

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Кандидат медицинских наук, доцент, начальник отделения реабилитации СПб ГБУЗ «Городская больница № 40», г. Сестрорецк, 197706, г. Санкт-Петербург

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版权所有 © Babkin A.V., Berdinskih I.S., Osechkina N.S., Nazarov G.V., Judin M.A., Bykov V.N., Sarana A.M., 2014


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