Email this article SAFETY TOXICOLOGICAL ASSESSMENT OF LEBENIN, ACTIvE SUBSTANCE OF LINEX
- Authors: Sheina N.I.1, Skrjabina J.G.1, Mjalina L.I.1, Budanova E.V.2, Sazonova L.P.1, Kolesnikova V.V.1, Chub G.G.1
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Affiliations:
- State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical University»
- State Budgetary Educational Institution of Higher Professional Education «I.M. Sechenov First Moscow State Medical University», RF Ministry of Healthcare
- Issue: No 2 (2015)
- Pages: 57-59
- Section: New information on toxicity and hazard of chemical and biological substances
- Published: 06.08.2021
- URL: https://vestnik.nvsu.ru/0869-7922/article/view/641339
- DOI: https://doi.org/10.15690/vramn451
- ID: 641339
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Abstract
Safety assessment of the preparation Lebenin was carried out. Lebenin contains a community of resistant to antibiotic drugs, viable lyophilized lactate bacteria of the following types: Lactobacillus gasseri ( s.v. L.acidophilus), Bifidobacterium infantis, Enterococcus foecium. The analysis of materials related to the substantiation of MACs of bacterial preparations and their ingredients in workplace and atmosphere in residential settings witnesses that there are already established hygiene norms for similar preparations and likely microorganisms in their compositions and therefore the above said microorganism preparations can be referred to hazard class 4.
About the authors
Natalia Ivanovna Sheina
State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical University»
Author for correspondence.
Email: fake@neicon.ru
Доктор биологических наук, доцент, профессор кафедры гигиены ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» МЗ РФ, 117997, г. Москва
e-mail: ni_sheina@mail.ru
Russian FederationJemilija Grigor’evna Skrjabina
State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical University»
Email: fake@neicon.ru
Кандидат медицинских наук, старший научный сотрудник отдела медицинской химии и токсикологии ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» МЗ РФ, 117997, г. Москва
e-mail: let@mail.ru
Russian FederationLjubov’ Ivanovna Mjalina
State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical University»
Email: fake@neicon.ru
Кандидат медицинских наук, доцент, доцент кафедры гигиены ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» МЗ РФ, 117997, г. Москва
e-mail: gigea@rsmu.ru
Russian FederationElena Vjacheslavovna Budanova
State Budgetary Educational Institution of Higher Professional Education «I.M. Sechenov First Moscow State Medical University», RF Ministry of Healthcare
Email: fake@neicon.ru
Кандидат медицинских наук, доцент, доцент кафедры микробиологии, вирусологии и иммунологии ГБОУ ВПО «Первый Московский государственный медицинский университет имени И.М. Сеченова» МЗ РФ, 119991 г. Москва,
e-mail: e.v.budanova@mail.ru
Russian FederationLjubov’ Pavlovna Sazonova
State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical University»
Email: fake@neicon.ru
Кандидат медицинских наук, старший преподаватель кафедры гигиены ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» МЗ РФ, 117997, г. Москва
e-mail: gigea@rsmu.ru
Russian FederationValentina Vasil’evna Kolesnikova
State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical University»
Email: fake@neicon.ru
Кандидат медицинских наук, старший преподаватель кафедры гигиены ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» МЗ РФ, 117997, г. Москва
e-mail: gigea@rsmu.ru
Russian FederationGalina Georgievna Chub
State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical University»
Email: fake@neicon.ru
Кандидат медицинских наук, старший преподаватель кафедры гигиены ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» МЗ РФ, 117997, г. Москва
e-mail: gigea@rsmu.ru
Russian FederationReferences
- Criteria of assessment the pathogenic properties of producer strains proposed for use in industrial microbiological synthesis. Methodical. recommendations, Medical University, Moscow, 1992, 22 p. (in Russian)
- Guidelines on experimental justification of the limit permitted concentration of producing microorganisms and their containing strains products in industrial and environmental objects . N5789/1-91. - M., 1991.- 22 p. (in Russian).
- Bergey’s Manual of Determinative Bacteriology. Ninth Ed. J. G. Holt, N. R. Krieg, P.H.A. Sneath et al. -M., “Mir”. -1997. - 2v. (in Russian).
- Limit permitted concentration of microorganisms-producer, bacterial preparations and their components in the air of settlements and in the working area. HN 2.1.6.2177-07, HN 2.2.6.2178-07. 06.03.2007. № №9, 10 (in Russian).
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