TOXICOLOGICAL PARADOXES IN MODERN NARCOLOGY

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

The need for an interdisciplinary approach to the examination of the chemicals-related addictive disorders problem is discussed. It is emphasized that the exaggeration of the role of any scientific vector cannot contribute to the progress in this area of biology and medicine. It is shown on the example of heroin and ethanol that the study of their toxicokinetics and toxicodynamics is far from being completed. That complicates the understanding of the drug addiction and alcoholism development mechanisms. This situation is denoted as one of the paradoxes in modern narcology. Another paradox is examined in connection with the «dose- effect» relationship.. It is shown that the neurochemical pattern, which accompanies exposures to psycho-active substances, can be substantially modified with the procedure for narcotization (alcoholization). A similar uncertainty can require the standardization of some studies in narcology.

Авторлар туралы

Alexander Golovko

«Institute of Toxicology» of federal Medico-biological Agency

Хат алмасуға жауапты Автор.
Email: prgolovko@inbox.ru

Доктор медицинских наук, профессор, ведущий научный сотрудник ФГБУН «Институт токсикологии Федерального медико-биологического агентства», 192019, г. Санкт-Петербург

e-mail: prgolovko@inbox.ru

Ресей

Genrikh Sofronov

«Institute of Experimental Medicine of the North-west branch of the Russian Academy of Medical Sciences»

Email: iem@iemrams.ru

Академик РАН, директор ФГБУ «Научно-исследовательский институт экспериментальной медицины» СЗО РАМН, 197376, г. Санкт-Петербург

e-mail: iem@iemrams.ru

Ресей

Alexander Sofronov

St.-Petersburg Medical Academy of Postgraduate Education

Email: noemail@neicon.ru

Доктор медицинских наук, профессор, заведующий кафедрой психиатрии Санкт-Петербургской медицинской академии последипломного образования, главный нарколог Комитета по здравоохранению Правительства СанктПетербурга, 191015, г. Санкт-Петербург

e-mail: alex-sofronov@yandex.ru

Ресей

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© Golovko A.I., Sofronov G.A., Sofronov A.G., 2015


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