Enviar artigo por via de e-mail STUDY OF THE TOXIC PROPERTIES OF 3-CHLOROPROPYL AND 6-CHLOROHEXYL ACRYLATES WITH JUSTIFICATION OF APPROXIMATELY SAFE LEVEL OF EXPOSURE IN THE AIR OF THE WORKING AREA
- Autores: Sychik S.I.1, Vasilkevich V.M.1, Bogdanov R.V.1, Bondarenko L.M.1, Bujnickaja A.V.1
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Afiliações:
- Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus
- Edição: Nº 5 (2019)
- Páginas: 26-32
- Seção: Articles
- ##submission.datePublished##: 28.10.2019
- URL: https://vestnik.nvsu.ru/0869-7922/article/view/641188
- DOI: https://doi.org/10.36946/0869-7922-2019-5-26-32
- ID: 641188
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Resumo
The article presents the results of the study on toxicity of 3-chloropropyl and 6-chlorohexyl acrylates in acute (at the level of lethal and sublethal doses and concentrations) and subchronic experiments (dose-monotone intake at the level of 0.1 DL50 per os for 45 days), which allowed to justify the value of approximately safe levels of exposure for chemicals in the air of the working area. Scientifically substantiated values of approximately safe exposure levels for 3-chloropropyl acrylate at 5 mg/m3 and for 6-chlorohexyl acrylate at 2 mg/m3 have been established.
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Sobre autores
S. Sychik
Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus
Autor responsável pela correspondência
Email: rspch@rspch.by
Sychik Sergei Ivanovich
220012, Minsk BelarusV. Vasilkevich
Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus
Email: sabas2004@mail.ru
Vasilkevich Vadim Michailovich
220012, Minsk BelarusR. Bogdanov
Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus
Email: 7_rus@tut.by
Bogdanov Ruslan Valerievich
220012, Minsk
BelarusL. Bondarenko
Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus
Email: fake@neicon.ru
Bondarenko Ljudmila Mihailovna
220012, Minsk
BelarusA. Bujnickaja
Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus
Email: fake@neicon.ru
Bujnickaja Anna Vasil’evna
220012, Minsk
BelarusBibliografia
- Methodological instructions for the experimental substantiation of the MPC of microorganisms-producers and the finished forms of preparations containing them in the objects of production and the environment: methodological instructions No 5789/ 1-91. Moscow; 1993 (in Russian).
- Belen'kiy M.L. Elements of quantitative evaluation of the pharmacological effect. Leningrad: Medgiz; 1963 (in Russian).
- Requirements for the formulation of experimental studies on the study of allergenic properties and the justification of the maximum allowable concentrations of chemical allergens in the air of the working area and atmosphere: methodological instructions No 1.1.11-12-5-2003. In: Filonov V.P., Sokolov S.M., eds. Collection of official documents on occupational medicine and production. Minsk; 2004. 133-56 (in Russian).
- State Standard 12.1.007-76. SSTB. Noxious substances. Classification and general safety requirements. Minsk: BelGISS; 2008 (in Russian).
- Izmerov N.F., Sanotskiy I.V., Sidorov K.K. Toxicometry parameters of industrial poisons upon single exposure: a handbook. Moscow: Meditsina; 1977 (in Russian).
- Experimental justification and calculation of hazardous materials in the air of the working area Experimental justification and calculation of the indicative safe exposure levels of harmful substances in the air of the working area: guidelines: methodological recommendations МR 118-00-10-2000. Minsk; 2010 (in Russian).
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