ROLE OF THE STROMAL CELLULAR COMPONENT IN COMPENSATORY PROCESSES IN DIFFUSE LIVER DAMAGE

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The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

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Z. Shafigullina

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of RAS

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S. Medvedeva

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of RAS

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I. Danilova

Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Natural Sciences and Mathematics; Institute of Immunology and Physiology, Ural Branch of RAS

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版权所有 © Shafigullina Z.A., Medvedeva S.Y., Danilova I.G., 2018


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