CONTENT OF METALLOTHIONEINS AND THE TOTAL PROTEIN IN SHEEP PERIPHERAL BLOOD LYMPHOCYTES UNDER CHRONIC DIETARY INTAKE OF LEAD NITRATE

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The content of the total protein and metallothioneins in peripheral blood lymphocytes of sheep which received lead nitrate with the diet in concentration of 5;25 and 150 mg/kg fodder was examined. Blood samples were taken from the sheep jugular vein before feeding on 7, 14, 28, 42, 70 and 90 days of investigation. The chronic intake of lead with the diet by the sheep organism is characterized by an increased level of metallothioneins in peripheral blood lymphocytes with simultaneous decrease of animals viability. At the same time, the amount of the total protein in the initial period of intoxication raises and in the subsequent periods decreases. Based on results obtained, it is suggested to use the determination of the metallothioneins content in peripheral blood lymphocytes as informative parameter to estimate mammalians exposure to lead.

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Eldeniz Mirzoev

State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences

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Email: noemail@neicon.ru

Доктор биологических наук, ведущий научный сотрудник лаборатории радиобиологии и экотоксикологии сельскохозяйственных животных ГНУ ВНИИСХРАЭ, 249032, г. Обнинск, Калужская обл.,

e-mail: mirzoev.ed@yandex.ru

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Vladimir Kobyalko

State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences

Email: noemail@neicon.ru

Кандидат биологических наук, старший научный сотрудник лаборатории радиобиологии и экотоксикологии сельскохозяйственных животных ГНУ ВНИИСХРАЭ, 249032, г. Обнинск, Калужская обл.,

e-mail: kobyalko@yandex.ru

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Irina Polyakova

State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences

Email: noemail@neicon.ru

Младший научный сотрудник лаборатории радиобиологии и экотоксикологии сельскохозяйственных животных ГНУ ВНИИСХРАЭ, 249032, г. Обнинск, Калужская обл.

e-mail: irinaamchenkina@mail.ru

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Olga Gubina

State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences

Email: noemail@neicon.ru

Научный сотрудник лаборатории радиобиологии и экотоксикологии сельскохозяйственных животных ГНУ ВНИИСХРАЭ, 249032, г. Обнинск, Калужской обл.

e-mail: Olgubina@yandex.ru

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Natalya Frolova

State Scientific Institution» All-Russian Institute of Agricultural Radiology and Agroecology», Russian Academy of Agricultural Sciences

Email: noemail@neicon.ru

Кандидат биологических наук, научный сотрудник лаборатории радиобиологии и экотоксикологии сельскохозяйственных животных ГНУ ВНИИСХРАЭ, 249032, г. Обнинск, Калужская обл.

e-mail: nafc@yandex.ru

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参考

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版权所有 © Mirzoev E.B., Kobyalko V.O., Polyakova I.V., Gubina O.A., Frolova N.A., 2014


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