EFFECT OF PEGYLATED GRAPHENE OXIDE NANOPARTICLES ON THE METABOLISM OF JURKAT CELLS

V. P. Timganova; Тимганова В. П.; V. V. Vlasova; Власова В. В.; M. S. Bochkova; Бочкова М. С.; K. Yu. Shardina; Шардина К. Ю.; S. V. Uzhviyuk; Ужвиюк С. В.; P. V. Khramtsov; Храмцов П. В.; M. B. Rayev; Раев М. Б.; S. A. Zamorina; Заморина С. А.

doi:10.31857/S2686738923600292

EFFECT OF PEGYLATED GRAPHENE OXIDE NANOPARTICLES ON THE METABOLISM OF JURKAT CELLS

Authors: Timganova V.P.¹, Vlasova V.V.¹, Bochkova M.S.¹^,2, Shardina K.Y.¹, Uzhviyuk S.V.¹, Khramtsov P.V.¹^,2, Rayev M.B.¹^,2, Zamorina S.A.¹^,2
Affiliations:
1. Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences
2. Perm State National Research University
Issue: Vol 512, No 1 (2023)
Pages: 470-473
Section: Articles
URL: https://vestnik.nvsu.ru/2686-7389/article/view/651075
DOI: https://doi.org/10.31857/S2686738923600292
EDN: https://elibrary.ru/TASLVY
ID: 651075

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Abstract

The effect of graphene oxide (GO) nanoparticles of 100–200 nm size coated with linear (LP-GO) and branched (BP-GO) polyethylene glycol at concentrations of 5 and 25 μg/mL on the metabolism of Jurkat tumor cells was studied. It was found that LP-GO nanoparticles at a concentration of 25 μg/mL can enhance basal glycolysis of Jurkat T lymphocyte tumor cell line cells, while LP-GO and BP-GO at the same concentration can reduce the indicators of compensatory glycolysis. Despite this, GO nanoparticles coated with linear and branched PEG at a concentration of 5 μg/mL do not have pronounced effects on oxidative phosphorylation and glycolysis of Jurkat cells and could therefore be safe for activated T cells.

Keywords

PEGylated graphene oxide nanoparticles, Jurkat cell line, metabolism, mitochondrial respiration, aerobic glycolysis

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