THE ROLE OF NEUROHUMORAL IMBALANCE AT POST-TRAUMATIC STRESS DISORDER IN THE ANTITUMOR IMMUNE RESPONSE. EXPERIMENTAL STUDY

M. V. Kondashevskaya; Кондашевская М. В.; K. A. Artemieva; Артемьева К. А.; V. V. Aleksankina; Алексанкина В. В.; V. V. Kudelkina; Куделькина В. В.; A. M. Kosyreva; Косырева А. М.; D. A. Areshidze; Арешидзе Д. А.; M. A. Kozlova; Козлова М. А.; L. M. Mikhaleva; Михалева Л. М.

doi:10.31857/S2686738923600127

THE ROLE OF NEUROHUMORAL IMBALANCE AT POST-TRAUMATIC STRESS DISORDER IN THE ANTITUMOR IMMUNE RESPONSE. EXPERIMENTAL STUDY

Authors: Kondashevskaya M.V.¹, Artemieva K.A.¹, Aleksankina V.V.¹, Kudelkina V.V.¹, Kosyreva A.M.¹, Areshidze D.A.¹, Kozlova M.A.¹, Mikhaleva L.M.¹
Affiliations:
1. Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Issue: Vol 511, No 1 (2023)
Pages: 333-339
Section: Articles
URL: https://vestnik.nvsu.ru/2686-7389/article/view/651083
DOI: https://doi.org/10.31857/S2686738923600127
EDN: https://elibrary.ru/IYYKGS
ID: 651083

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Abstract

The aim of the study was to investigate the growth and development of B16 melanoma in mature male C57Black/6 mice with a post-traumatic stress disorder (PTSD) model. Behavioral, immunohistochemical, morphometric methods, enzyme immunoassay were used. A forced decrease in the level of corticosterone, which is characteristic for PTSD, was established, followed by an intensification of the production of increased concentrations of pro-inflammatory interleukins by the cells of the immune system and, at the same time, a decrease in the secretion of anti-inflammatory cytokines. Priority data were obtained: the neurohumoral imbalance that develops in PTSD is a limiting factor to the growth of B16 melanoma, at least at the initial stages of the oncological process.

Keywords

mice, В16 melanoma, post-traumatic stress disorder, interleukins, corticosterone

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