NEW PLANT SPECIES SHOWING ANTIPROTOZOIAN ACTIVITY

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Abstract

The effects of extracts of ten plant species growing in Russia and five species growing in Vietnam on the growth and survival of ciliates Tetrahymena pyriformis were studied. T. pyriformis is from the Protozoa subkingdom, which also includes pathogens of protozoan infections. Extraction of dried plants was carried out with acidic and alkaline aqueous solutions, as well as with an aqueous ethanol solution. Various amounts of extracts were added to the infusoria cells and the number of survived cells was recorded after 1 and 24 hours. We found that our samples of several plants, including wormwood, harmala, and licorice, similarly to those studied earlier, have antiprotozoal activity, which may indicate a sameness of secondary metabolites in plants from different regions. Using the ciliate T. pyriformis as a model organism, the presence of antiprotozoal activity in extracts of lilac, chondrilla, cinquefoil, hop and elm was shown for the first time.

About the authors

E. G. Cheremnykh

Mental Health Research Centre

Email: utkin@ibch.ru
Russian Federation, Moscow

A. V. Osipov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: utkin@ibch.ru
Russian Federation, Moscow

V. G. Starkov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: utkin@ibch.ru
Russian Federation, Moscow

Nguyen Thi Thuy Trang

Nguyen Tat Thanh University

Email: utkin@ibch.ru
Vietnam, Ho Chi Minh City

Nguyen Cuu Khoa

Institute of Applied Materials Science, Vietnam Academy of Science and Technology

Email: utkin@ibch.ru
Vietnam, Ho Chi Minh City

Hoang Ngoc Anh

Institute of Applied Materials Science, Vietnam Academy of Science and Technology

Email: utkin@ibch.ru
Vietnam, Ho Chi Minh City

Le Tien Dung

Institute of Applied Materials Science, Vietnam Academy of Science and Technology

Email: utkin@ibch.ru
Vietnam, Ho Chi Minh City

V. I. Tsetlin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: utkin@ibch.ru
Russian Federation, Moscow

Yu. N. Utkin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: utkin@ibch.ru
Russian Federation, Moscow

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Copyright (c) 2023 Е.Г. Черемных, А.В. Осипов, В.Г. Старков, Ч.Т.Т. Нгуен (Nguyen Thi Thuy Trang), Х.К. Нгуен (Nguyen Cuu Khoa), А.Н. Хоанг (Hoang Ngoc Anh), З.Т. Ле (Le Tien Dung), В.И. Цетлин, Ю.Н. Уткин