184–188 NUCLEOTIDES DELETION OF HUMAN TELOMERASE RNA DOES NOT AFFECT ON THE TELOMERASE FUNCTIONING

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

Telomerase is a ribonucleoprotein complex, the main components of which are telomerase RNA and reverse transcriptase. Previously, it was shown in our laboratory that human telomerase RNA contains an open reading frame, starting at adenine in position 176. The open reading frame encodes the hTERP protein, and the deletion of nucleotides 184–188 of human telomerase RNA disrupts the open reading frame and leads to the absence of hTERP. Human telomerase RNA has a conserved structure, changes in which affect telomerase activity. In this work, we have shown that the deletion of nucleotides 184–188 of telomerase RNA does not affect the functioning of telomerase.

Негізгі сөздер

Авторлар туралы

V. Shliapina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Lomonosov Moscow State University, Department of Chemistry

Хат алмасуға жауапты Автор.
Email: vikyl4es@gmail.com
Russian Federation, Moscow; Russian Federation, Moscow

O. Dontsova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Lomonosov Moscow State University, Department of Chemistry; A.N. Belozersky Institute of Physico-Chemical Biology; Center of Life Sciences, Skolkovo Institute of Science and Technology

Email: vikyl4es@gmail.com
Russian Federation, Moscow; Russian Federation, Moscow; Russian Federation, Moscow; Russian Federation, Moscow

M. Rubtsova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Lomonosov Moscow State University, Department of Chemistry

Email: vikyl4es@gmail.com
Russian Federation, Moscow; Russian Federation, Moscow

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© В.Л. Шляпина, О.А. Донцова, М.П. Рубцова, 2023