Мақаланы E-mail арқылы жіберу Efficacy of poloxamer 188 in aplastic anemia model induced by carboplatin in CBA mice
- Авторлар: Kholina A.V.1,2, Palikov V.A.1, Borozdina N.A.1, Kravchenko I.N.1, Pakhomova I.A.1, Dalevich R.A.1,2, Hajiguliyeva S.Z.1, Arshintseva E.V.3, Pushkin S.Y.3, Dyachenko I.A.1, Murashev A.N.1
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Мекемелер:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
- Medical emulsions LLC
- Шығарылым: Том 520, № 1 (2025)
- Беттер: 26-30
- Бөлім: Articles
- URL: https://vestnik.nvsu.ru/2686-7389/article/view/682023
- DOI: https://doi.org/10.31857/S2686738925010056
- EDN: https://elibrary.ru/tcybfa
- ID: 682023
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
The efficacy of poloxamer 188 on medullary hematopoiesis in aplastic anemia was investigated. The present study demonstrated that poloxamer 188 at doses of 10 mg/kg, 100 mg/kg and 500 mg/kg administered via oral gavage in CBA mice, in the context of the development of anemia, a dose-dependent effect was observed, characterized by an increase in erythrocyte, hemoglobin and reticulocyte numbers. In the group with carboplatin, these parameters were decreased on day 21, indicating mild anemia. It has been established that P188 has the capacity to exert a beneficial influence on the blood cell composition, which is disrupted by cytostatic drugs.
Негізгі сөздер
Толық мәтін
Авторлар туралы
A. Kholina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
Email: borozdina@bibch.ru
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
Ресей, Pushchino; PushchinoV. Palikov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Ресей, PushchinoN. Borozdina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: borozdina@bibch.ru
Branch
Ресей, PushchinoI. Kravchenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Ресей, PushchinoI. Pakhomova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Ресей, PushchinoR. Dalevich
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
Email: borozdina@bibch.ru
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
Ресей, Pushchino; PushchinoS. Hajiguliyeva
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Ресей, PushchinoE. Arshintseva
Medical emulsions LLC
Email: borozdina@bibch.ru
Ресей, Serpukhov
S. Pushkin
Medical emulsions LLC
Email: borozdina@bibch.ru
Ресей, Serpukhov
I. Dyachenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Ресей, PushchinoA. Murashev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Ресей, PushchinoӘдебиет тізімі
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