The aim of this research is to evaluate the influence of selenium on the balance of microelements (i.e. Fe, Zn, Cu, Cr, Co, I, Mo) in the liver of Wistar rats. The subjects of research were as follows: liver of Wistar rats, microelements (Fe, Zn, Cu, Cr, Co, I, Mo). The experimental animals received a standard laboratory diet, for four months selenium solution in the form of Na2SiO3 was daily included into the diet of the experimental group “Selenium”. Liver was used as a material for studies. The physiological role of selenium is a subject of extensive scientific research. The main function of selenium is, first of all, its participation in antioxidant processes. Despite numerous studies confirming the need for selenium presence in the organism of animals and people, there is also a proven evidence of its toxicity when its concentration exceeds the maximum accepted levels. While the influence of selenium on plants has been studied thoroughly; the mechanism of this microelement influence on animal or human bodies requires additional study. The following data have been obtained: when the solution of Na2SiO3 is introduced into the body of animals, an increase in the content of the following microelements takes place, i.e. Co - 121.14%, I - 21.41%, Mn - 23.19%, Fe - 35.39%. The content of chrome has decreased by 55.43% as a result of selenium influence. The content of copper and zinc in the rat liver has not changed significantly under the influence of selenium.
selen, makro- i mikroelementy, zhivotnyy organizm, pechen'
1. Boev V. M. 2002. Sreda obitaniya i ekologicheski obuslovlennyy disbalans mikroelementov u naseleniya urbanizirovannyh i sel'skih territoriy // Gigiena i sanitariya 5, 3-8.
2. Georgievskiy V. I., Annenkov B. N., Samohin V. T. 1979. Mineral'noe pitanie zhivotnyh. Moskva: Kolos.
3. Golubkina N. A., Sindireva A. V., Zaycev V. F. 2017. Vnutriregional'naya variabel'nost' selenovogo statusa naseleniya // Yug Rossii: ekologiya, razvitie. T. 12, № 1, 107-127.
4. Gorbachev V. V., Gorbacheva V. N. 2002. Vitaminy, mikro- i makroelementy. Spravochnik Minsk: Knizhnyy Dom; Interpresservis.
5. Zapadnyuk I. P., Zapadnyuk V. I., Zahariya E. A., Zapadnyuk B. V. 1974. Laboratornye zhivotnye. Kiev.
6. Isidorov V. A. 2001. Ekologicheskaya himiya. Sankt-Peterburg: Himizdat.
7. Kaplin V. G. 2006. Osnovy ekotoksikologii. Moskva: KolosS.
8. Sindireva A. V. 2011. Ekologo-toksikologicheskaya ocenka deystviya kadmiya, cinka, selena v usloviyah yuzhnoy lesostepi Omskoy oblasti // Vestnik Krasnoyarskogo gos. agrarnogo un-ta 10, 118-122.
9. Sindireva A. V., Krasnickiy V. M., Ermohin Yu. I. 2012. Regional'nye osobennosti kadmiya i cinka v pochvah Omskoy oblasti // Plodorodie 1, 47-50.
10. Skal'nyy A. V., Rudakov I. A. 2004. Bioelementy v medicine. Moskva: ONIKS 21 vek; Mir i Obrazovanie.
11. Cimmermann Maykl. 2006. Mikroelementy v medicine (po Burgershtaynu) / Per s nem. Moskva: Arnebiya.
12. Andrew McCartor J. D., Dan Becker B.A. 2010. The worst pollution problems in the world. Top six toxic threats.
13. Klotz L. O., Kroncke K. D., Buchczyk D. P., Sies H. 2003. Role of copper, zinc, selenium, tellurium in the cellular defense against oxidative and nitrosative stress // Journal of Nutrition 133 (5), 1448-1451.
14. Räber M., Geyer H., Kessler J., Gutzwiller A. 2008. Effects of high selenium intake on selenium status, liver function and claw health of fattening bulls // SAT Schweizer Archiv für Tierheilkunde, 56-57.
15. Steinbrenner H., Alili L., Bilgic E., Sies H., Brenneisen P. 2006. Involvement of selenoprotein P in protection of human astrocytes from oxidative damage // Free Radic Biol Med. 40, 1513-1523.
16. Tapiero H., Townsend D. M., Tew K. D. 2003. The antioxidant role of selenium and seleno-compounds // Biomed Pharm. 57, 134-144.



