D2-LIKE DOPAMINE RECEPTOR DISTRIBUTION IN THE BRAIN OF RATS WITH DIFFERENT TYPES OF GENETIC EPILEPSY

E. T. Tsyba; Цыба Е. Т.; L. M. Birioukova; Бирюкова Л. М.; I. S. Midzyanovskaya; Мидзяновская И. С.; N. M. Surina; Сурина Н. М.; K. R. Abbasova; Аббасова К. Р.

doi:10.31857/S2686738922700147

D2-LIKE DOPAMINE RECEPTOR DISTRIBUTION IN THE BRAIN OF RATS WITH DIFFERENT TYPES OF GENETIC EPILEPSY

Authors: Tsyba E.T.¹, Birioukova L.M.², Midzyanovskaya I.S.², Surina N.M.¹, Abbasova K.R.¹
Affiliations:
1. Lomonosov Moscow State University, Faculty of Biology
2. Institute of Higher Nervous Activity and Neurophysiology of RAS (IHNA&NPh RAS)
Issue: Vol 509, No 1 (2023)
Pages: 161-165
Section: Articles
URL: https://vestnik.nvsu.ru/2686-7389/article/view/651129
DOI: https://doi.org/10.31857/S2686738922700147
EDN: https://elibrary.ru/NBICLX
ID: 651129

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Abstract

The study investigated D2-like dopamine receptor (D2DR) binding densities in cortex and striatum between rats with absence and/or audiogenic genetically determined epilepsy and normal Wistar rats by autoradiography. It was shown that D2DR binding density was lower in the dorsal and ventrolateral aspects of nucleus accumbens in epileptic vs non-epileptic rats. Additionally, audiogenic rats had higher motor, somatosensory cortex, and dorsal striatum binding as in contrast with non-audiogenic groups. This data suggests that there is a common neuronal circuit involved in the pathogenesis of generalized epilepsy of both convulsive and non-convulsive forms.

Keywords

absence epilepsy, audiogenic epilepsy, dopamine, neurotransmitter, autoradiography, WAG/Rij, KM

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