D2-LIKE DOPAMINE RECEPTOR DISTRIBUTION IN THE BRAIN OF RATS WITH DIFFERENT TYPES OF GENETIC EPILEPSY

E. T. Tsyba; Цыба Е. Т.; L. M. Birioukova; Бирюкова Л. М.; I. S. Midzyanovskaya; Мидзяновская И. С.; N. M. Surina; Сурина Н. М.; K. R. Abbasova; Аббасова К. Р.

doi:10.31857/S2686738922700147

D2-LIKE DOPAMINE RECEPTOR DISTRIBUTION IN THE BRAIN OF RATS WITH DIFFERENT TYPES OF GENETIC EPILEPSY

作者: Tsyba E.T.¹, Birioukova L.M.², Midzyanovskaya I.S.², Surina N.M.¹, Abbasova K.R.¹
隶属关系:
1. Lomonosov Moscow State University, Faculty of Biology
2. Institute of Higher Nervous Activity and Neurophysiology of RAS (IHNA&NPh RAS)
期: 卷 509, 编号 1 (2023)
页面: 161-165
栏目: Articles
URL: https://vestnik.nvsu.ru/2686-7389/article/view/651129
DOI: https://doi.org/10.31857/S2686738922700147
EDN: https://elibrary.ru/NBICLX
ID: 651129

如何引用文章

全文:

开放存取

##reader.subscriptionAccessGranted##
受限制的访问

订阅存取

详细

The study investigated D2-like dopamine receptor (D2DR) binding densities in cortex and striatum between rats with absence and/or audiogenic genetically determined epilepsy and normal Wistar rats by autoradiography. It was shown that D2DR binding density was lower in the dorsal and ventrolateral aspects of nucleus accumbens in epileptic vs non-epileptic rats. Additionally, audiogenic rats had higher motor, somatosensory cortex, and dorsal striatum binding as in contrast with non-audiogenic groups. This data suggests that there is a common neuronal circuit involved in the pathogenesis of generalized epilepsy of both convulsive and non-convulsive forms.

关键词

absence epilepsy, audiogenic epilepsy, dopamine, neurotransmitter, autoradiography, WAG/Rij, KM

参考

Russo E., Citraro R., Constanti A., et al. Upholding WAG/Rij rats as a model of absence epileptogenesis: Hidden mechanisms and a new theory on seizure development // Neuroscience & Biobehavioral Reviews. 2016. V. 71. P. 388–408.
Poletaeva I., Surina N., Kostina Z., et al. The Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65years // Epilepsy Behav. 2017. V. 71. Pt. B. P. 130–141.
Kuznetsova G., Petrova E., Coenen A., et al. Generalized absence epilepsy and catalepsy in rats // Physiol. Behav. 1996. V. 60. P. 1165–1169.
Birioukova L., Midzyanovskaya I., Lensu S., et al. Distribution of D1-like and D2-like dopamine receptors in the brain of genetic epileptic WAG/Rij rats // Epilepsy Res. 2005. V. 63. № 2–3. P. 89–96.
Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates // Academic Press, Sixth Edition, 2007.
Midzyanovskaya et al. The prefrontal cortex shows widespread decrease in H3 histamine receptor binding densities in rats with genetic generalized epilepsies // Epilepsy Res. 2022. V. 182. 106921.
Deransart C., Riban V., Lê B., et al. Dopamine in the striatum modulates seizures in a genetic model of absence epilepsy in the rat // Neuroscience. 2000. V. 100. № 2. P. 335–44.
Fu J., Liu Y., Yang K., Long H., Wang K., Qi S. Effect of accumbens nucleus shell lesioning on bitemporal lobe epilepsy in rat model // Folia Neuropathologica. 2018. V. 56. № 4. P. 346–353.
Wang J., Zhang Y., Zhang H., et al. Nucleus accumbens shell: A potential target for drug-resistant epilepsy with neuropsychiatric disorders // Epilepsy Res. 2020. V. 164. 106365.
Zhao X., Yang R., Wang K., et al. Connectivity-based parcellation of the nucleus accumbens into core and shell portions for stereotactic target localization and alterations in each NAc subdivision in mTLE patients // Hum. Brain Mapp. 2018. V. 39. P. 1232–1245.
al-Tajir G., Starr M.S. Anticonvulsant effect of striatal dopamine D2 receptor stimulation: dependence on cortical circuits? // Neuroscience. 1991. V. 43. № 1. P. 51–7.
Fedotova I., Surina N., Nikolaev G., et al. Rodent Brain Pathology, Audiogenic Epilepsy // Biomedicines. 2021. V. 9. № 11. P. 1641.
Deransart C., et al. Up-regulation of D3 dopaminergic receptor mRNA in the core of the nucleus accumbens accompanies the development of seizures in a genetic model of absence-epilepsy in the rat // Molecular Brain Research. 2001. V. 94. P. 166–177.